A COMPARISON OF WIN-51711 AND R-78206 AS STABILIZERS OF POLIOVIRUS VIRIONS AND PROCAPSIDS

被引:44
作者
ROMBAUT, B
ANDRIES, K
BOEYE, A
机构
[1] VRIJE UNIV BRUSSELS,DEPT MICROBIOL & HYG,LAARBEEKLAAN 103,B-1090 BRUSSELS,BELGIUM
[2] JANSSEN RES FDN,B-2340 BEERSE,BELGIUM
关键词
D O I
10.1099/0022-1317-72-9-2153
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The thermal denaturation of poliovirus virions and procapsids in the 42 to 48-degrees-C range was studied using N- and H-specific monoclonal antibodies. The half-life of the N antigen of Mahoney and Sabin 1 virions was extended 50- to 250-fold by either 10-mu-M WIN 51711 or R 78206. The minimum concentrations required for full stabilization at 46-degrees-C (1.0-mu-M for WIN 51711, 0.2-mu-M for R 78206) were independent of the strain or serotype of the virus; 30 to 60 molecules of stabilizer per virion were required for full protection. R 78206 was the most efficient stabilizer of Mahoney procapsids; the half-life of the N-specific epitopes of these particles at 44-degrees-C was extended from less than 1 min to 1 day.
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页码:2153 / 2157
页数:5
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