IMMUNIZATION OF NONCOLONIZED CYSTIC-FIBROSIS PATIENTS AGAINST PSEUDOMONAS-AERUGINOSA

被引：31

作者：

CRYZ, SJ ^{[1
]}

WEDGWOOD, J ^{[1
]}

LANG, AB ^{[1
]}

RUEDEBERG, A ^{[1
]}

QUE, JU ^{[1
]}

FURER, E ^{[1
]}

SCHAAD, UB ^{[1
]}

机构：

[1] UNIV BERN,INSELSPITAL,DEPT PEDIAT,CH-3010 BERN,SWITZERLAND

来源：

JOURNAL OF INFECTIOUS DISEASES | 1994年 / 169卷 / 05期

关键词：

D O I：

10.1093/infdis/169.5.1159

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The long-term safety and immunogenicity of a polyvalent Pseudomonas aeruginosa conjugate vaccine was evaluated in 30 noncolonized cystic fibrosis patients. Four doses were administered over 3 years, and patients were followed for a mean of 38 months. No acute or long-term adverse effects were noted. Immunization engendered a significant antibody response to all vaccine components. A decline in titers during year 3 of observation was associated with a marked rise in the isolation of P. aeruginosa. This organism was isolated repeatedly from the respiratory tract of 4 patients and only once from 7 patients. The remaining patients were repeatedly culture-negative. Only 1 patient showed clinical deterioration associated with multiple isolations of P. aeruginosa.

引用

页码：1159 / 1162

页数：4

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