TANDEM ENYNE ALLENE-RADICAL CYCLIZATION VIA [3,3]-SIGMATROPIC REARRANGEMENTS

被引：30

作者：

GRISSOM, JW

HUANG, DH

机构：

[1] Department of Chemistry, University of Utah, Salt Lake City

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 18期

关键词：

D O I：

10.1021/jo00097a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enediynes 1, 7, 12, and 16 undergo a tandem [3,3] sigmatropic shift-enyne allene cyclization. Enediynes 7 and 16 are especially interesting because after undergoing a [3,3] sigmatropic shift and enyne allene cyclization, the resultant biradical undergoes a 5-exo radical cyclization. These reactions can be effected by either heating at 150 degrees C or by treatment with silver salts followed by heating at 75 degrees C.

引用

页码：5114 / 5116

页数：3

共 37 条

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