VASCULAR EVENTS IN EXPERIMENTAL OTITIS-MEDIA MODELS - A COMPARATIVE-STUDY

被引：11

作者：

GOLDIE, P

HELLSTROM, S

JOHANSSON, U

机构：

[1] Departments of Anatomy, University of Umeå

[2] Departments of Otorhinolaryngology and Head and Neck Surgery, University of Umeå

来源：

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1990年 / 52卷 / 02期

关键词：

Albumin; Experimental otitis media; Immunoglobulins; Middle ear effusion; Transferrin; Vascular leakage;

D O I：

10.1159/000276114

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The vascular leakage and components of middle ear effusion (MEE) were deter- mined and compared in various experimental otitis media models in the rat: Purulent otitis media (POM); serous otitis media (SOM); mucoid-like otitis media (MOM); stimulating the external auditory canal with a 14 °C airstream and vagotomy. When the Evans blue tech- nique was used, all otitis media models exhibited a significant increase in middle ear vessel permeability. The MEEs contained numerous PMNLs, except for animals stimulated with a 14 °C airstream, in which the MEE was free of cells. The IgG/SIgA ratio in MEEs indicated that the MEE components are derived from serum in the early phases of fluid accumulation, in these otitis media models. In POM, MEE components appeared to be derived from local synthesis by the middle ear mucosa as well. © 1990 S. Karger AG, Basel.

引用

页码：104 / 112

页数：9

共 23 条

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