BINARY ANTIDOTES FOR ORGANO-PHOSPHATE POISONING - APROPHEN ANALOGS THAT ARE BOTH ANTIMUSCARINICS AND CARBAMATES

被引：24

作者：

LEADER, H ^{[1
]}

SMEJKAL, RM ^{[1
]}

PAYNE, CS ^{[1
]}

PADILLA, FN ^{[1
]}

DOCTOR, BP ^{[1
]}

GORDON, RK ^{[1
]}

CHIANG, PK ^{[1
]}

机构：

[1] WALTER REED ARMY INST RES, DEPT APPL BIOCHEM, WASHINGTON, DC 20307 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 07期

关键词：

D O I：

10.1021/jm00127a020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1522 / 1528

页数：7

共 50 条

[1] DISPOSITION OF APROPHEN IN RATS [J].

AARBAKKE, J ;

MIURA, GA ;

BROWN, ND ;

GRAY, RR ;

GORDON, RK ;

DOCTOR, BP ;

CHIANG, PK .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1986, 38 (12) :928-930

[2] A MICROTECHNIQUE FOR QUANTIFICATION OF DETERGENT-SOLUBILIZED MUSCARINIC AND NICOTINIC ACETYLCHOLINE-RECEPTORS USING A SEMIAUTOMATED CELL HARVESTOR [J].

AHMAD, A ;

GORDON, RK ;

CHIANG, PK .

FEBS LETTERS, 1987, 214 (02) :285-290

[3]

AMITAI G, 1987, MOL PHARMACOL, V32, P678

[4] NATURE OF AN ANIONIC SITE IN BUTYRYLCHOLINESTERASE COMPARED WITH THAT OF A SIMILAR SITE IN ACETYLCHOLINESTERASE [J].

AUGUSTINSSON, KB .

BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 128 (02) :351-+

[5]

AUGUSTINSSON KB, 1948, ACTA PHYSIOL SCA S52, V15, P1

[6]

BEACH JE, 1988, J PHARMACOL EXP THER, V246, P548

[7] USE OF CARBAMATES AND ATROPINE IN PROTECTION OF ANIMALS AGAINST POISONING BY 1,2,2-TRIMETHYLPROPYL METHYLPHOSPHONOFLUORIDATE [J].

BERRY, WK ;

DAVIES, DR .

BIOCHEMICAL PHARMACOLOGY, 1970, 19 (03) :927-&

[8]

BIRDSALL NJM, 1984, TRENDS PHARM SCI S4, V5

[9] DESETHYLAPROPHEN - A METABOLITE OF APROPHEN WITH ANTIMUSCARINIC ACTIVITIES [J].

BROWN, ND ;

SMEJKAL, RM ;

BREUER, E ;

DOCTOR, BP ;

CHIANG, PK .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1988, 77 (02) :145-148

[10] 6-METHYL-6-AZABICYCLO[3.2.1]OCTAN-3-ALPHA-OL 2,2-DIPHENYLPROPIONATE (AZAPROPHEN), A HIGHLY POTENT ANTIMUSCARINIC AGENT [J].

CARROLL, FI ;

ABRAHAM, P ;

PARHAM, K ;

GRIFFITH, RC ;

AHMAD, A ;

RICHARD, MM ;

PADILLA, FN ;

WITKIN, JM ;

CHIANG, PK .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (05) :805-809

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