INSULIN-LIKE GROWTH FACTOR-I SUPPORTS EMBRYONIC NERVE-CELL SURVIVAL

被引：33

作者：

SVRZIC, D

SCHUBERT, D

机构：

[1] SALK INST BIOL STUDIES, POB 85800, SAN DIEGO, CA 92138 USA

[2] INST BIOCHEM, DEPT NEUROCHEM, YU-11000 BELGRADE, YUGOSLAVIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80172-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin-like growth factor 1 (IGF-1) is shown to support the long term survival of embryonic chicken central nervous system neurons cultured in a defined medium. This trophic activity for IGF-1 was discovered as the result of its presence as a contaminant in bovine serum albumin, a reagent frequently used in primary cultures of neuronal tissue. The observation that IGF-1 has cell survival activity may explain the high level of IGF-1 receptors found in embryonic brain. © 1990 Academic Press, Inc.

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页码：54 / 60

页数：7

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