DETERMINATION OF METHAMPHETAMINE, AMPHETAMINE AND PIPERIDINE IN HUMAN URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH CHEMILUMINESCENCE DETECTION

被引：39

作者：

HAYAKAWA, K ^{[1
]}

IMAIZUMI, N ^{[1
]}

ISHIKURA, H ^{[1
]}

MINOGAWA, E ^{[1
]}

TAKAYAMA, N ^{[1
]}

KOBAYASHI, H ^{[1
]}

MIYAZAKI, M ^{[1
]}

机构：

[1] ISHIKAWA PREFECTURAL POLICE HEADQUARTERS,FORENS SCI LAB,KANAZAWA 920,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 515卷

关键词：

D O I：

10.1016/S0021-9673(01)89341-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic method for the determination of trace levels of methamphetamine, amphetamine and piperidine in human urine is reported. The three compounds, extracted into diethyl ether from alkaline urine, were derivatized with dansyl chloride, then separated on a reversed-phase column and detected by chemiluminescence reaction with bis(2,4,6-trichlorophenyl) oxalate and hydrogen peroxide. The corresponding peaks obtained from human urine were identified as the dansyl derivatives by mass spectrometry. Methamphetamine levels as low as 2 · 10-10 M in urine were determined. The sensitivity of the method is higher than that of Simon's reagent test and gas chromatography. © 1990.

引用

页码：459 / 466

页数：8

共 21 条

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