ISOLATION OF CHINESE-HAMSTER OVARY CELL-LINES PRODUCING MAN3GLCNAC2 ASPARAGINE-LINKED GLYCANS

被引：26

作者：

ZENG, Y ^{[1
]}

LEHRMAN, MA ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT PHARMACOL,5323 HARRY HINES BLVD,DALLAS,TX 75235

来源：

ANALYTICAL BIOCHEMISTRY | 1991年 / 193卷 / 02期

关键词：

D O I：

10.1016/0003-2697(91)90020-T

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Chinese hamster ovary lines with two mutations, one causing accumulation of Man5GlcNAc2-P-P-dolichol and a second resulting in defective N-acetylglucosaminyltransferase I activity, synthesize asparagine-linked glycans with the structure Man3GlcNAc2. As a result, the asparagine-linked glycans produced by these lines are smaller and less heterogeneous than those produced by other currently available animal cell lines. © 1991.

引用

页码：266 / 271

页数：6

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