DNA GYRASE GYRA MUTATIONS IN CIPROFLOXACIN-RESISTANT STRAINS OF STAPHYLOCOCCUS-AUREUS - CLOSE SIMILARITY WITH QUINOLONE RESISTANCE MUTATIONS IN ESCHERICHIA-COLI

被引：142

作者：

SREEDHARAN, S

ORAM, M

JENSEN, B

PETERSON, LR

FISHER, LM

机构：

[1] UNIV LONDON ST GEORGES HOSP,SCH MED,DEPT CELLULAR & MOLEC SCI,DIV BIOCHEM,MOLEC GENET GRP,LONDON SW17 0RE,ENGLAND

[2] VET ADM MED CTR,INFECT DIS SECT,MINNEAPOLIS,MN 55417

来源：

JOURNAL OF BACTERIOLOGY | 1990年 / 172卷 / 12期

关键词：

D O I：

10.1128/jb.172.12.7260-7262.1990

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The gyrA genes isolated from three ciprofloxacin-resistant clinical isolates of Staphylococcus aureus carried codon 84 (serine → leucine) and/or codon 85 (serine → proline) mutations that were absent in pretreatment susceptible strains. These substitutions occur in a region of the gyrase A protein wherein directly analogous mutations of serine 83 → leucine and alanine 84 → proline in Escherichia coli confer quinolone resistance. Thus, DNA gyrase A subunit mutations are implicated in resistance to ciprofloxacin in S. aeureus.

引用

页码：7260 / 7262

页数：3

共 21 条

[1] CLONING AND CHARACTERIZATION OF A DNA GYRASE-A GENE FROM ESCHERICHIA-COLI THAT CONFERS CLINICAL RESISTANCE TO 4-QUINOLONES [J].

CULLEN, ME ;

WYKE, AW ;

KURODA, R ;

FISHER, LM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (06) :886-894

[2] CIPROFLOXACIN AND THE FLUOROQUINOLONES - NEW CONCEPTS ON THE MECHANISM OF ACTION AND RESISTANCE [J].

FISHER, LM ;

LAWRENCE, JM ;

JOSTY, IC ;

HOPEWELL, R ;

MARGERRISON, EEC ;

CULLEN, ME .

AMERICAN JOURNAL OF MEDICINE, 1989, 87 (5A) :S2-S8

[3] DNA GYRASE - ENZYME THAT INTRODUCES SUPERHELICAL TURNS INTO DNA [J].

GELLERT, M ;

MIZUUCHI, K ;

ODEA, MH ;

NASH, HA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (11) :3872-3876

[4] NALIDIXIC-ACID RESISTANCE - 2ND GENETIC CHARACTER INVOLVED IN DNA GYRASE ACTIVITY [J].

GELLERT, M ;

MIZUUCHI, K ;

ODEA, MH ;

ITOH, T ;

TOMIZAWA, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (11) :4772-4776

[5] ESCHERICHIA COLI K-12 MUTANTS RESISTANT TO NALIDIXIC ACID - GENETIC MAPPING AND DOMINANCE STUDIES [J].

HANE, MW ;

WOOD, TH .

JOURNAL OF BACTERIOLOGY, 1969, 99 (01) :238-&

[6]

HOPEWELL R, 1980, J BACTERIOL, V172, P3481

[7]

HOROWITZ DS, 1987, J BIOL CHEM, V262, P5339

[8]

ISAACS RD, 1988, LANCET, V2, P843

[9]

MATTHEWS PR, 1987, J GEN MICROBIOL, V133, P1919

[10] CIPROFLOXACIN FOR METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS INFECTIONS [J].

PIERCY, EA ;

BARBARO, D ;

LUBY, JP ;

MACKOWIAK, PA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (01) :128-130

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