GROWTH-HORMONE LOADED BIOACTIVE CERAMICS

被引：34

作者：

DOWNES, S

DISILVIO, L

KLEIN, CPAT

KAYSER, MV

机构：

[1] Institute of Orthopaedics, University College London, Stanmore, Middlesex, Brockley Hill

[2] Cobbold Laboratories, University College London, Thorn Institute of Clinical Science, London, W1N 8AA, Mortimer Street

[3] Department of Biomaterials, School of Medicine, University of Leiden, Leiden, 23333AA

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 1991年 / 2卷 / 03期

关键词：

D O I：

10.1007/BF00692977

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A 'bioactive' material, capable of active stimulation of osteogenesis, has been produced by adsorbing human growth hormone onto calcium phosphate ceramics. These materials can be used to deliver growth hormone at the bone-ceramic interface. The elution of the hormone occurs in two phases, with an initial rapid release followed by a slow continuous release for up to 25 days. Tricalcium phosphate was found to release growth hormone better than hydroxyapatite, probably due to the higher solubility of the ceramic. In vivo studies using a rabbit model were used to demonstrate osteointegration at the ceramic interface.

引用

页码：176 / 180

页数：5

共 10 条

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