THE LOSS OF BETA-II-PROTEIN KINASE-C IN THE STRIATUM FROM PATIENTS WITH HUNTINGTONS-DISEASE

被引：14

作者：

HASHIMOTO, T

KITAMURA, N

SAITO, N

KOMURE, O

NISHINO, N

TANAKA, C

机构：

[1] KOBE UNIV,SCH MED,DEPT PHARMACOL,7-5-1 KUSUNOKI CHO,CHUO KU,KOBE 650,JAPAN

[2] KOBE UNIV,SCH MED,DEPT PSYCHIAT & NEUROL,KOBE 650,JAPAN

来源：

BRAIN RESEARCH | 1992年 / 585卷 / 1-2期

关键词：

4-BETA-PHORBOL-12,13-DIBUTYRATE; PROTEIN KINASE-C; 2ND MESSENGER; HUNTINGTONS DISEASE; STRIATUM; POSTMORTEM BRAIN;

D O I：

10.1016/0006-8993(92)91224-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have examined the levels of protein kinase C (PKC) in autopsied brains of patients with Huntington's disease (HD), using [H-3]4-beta-phorbol-12,13-dibutyrate ([H-3] PDBu) and antisera against the PKC subspecies. In the caudate nucleus and putamen from patients with HD, the specific binding for [H-3]PDBu was significantly decreased by 74 and 68%, respectively, as compared to findings in controls. The beta-II-PKC immunoreactivities were significantly reduced by 65%, whereas the alpha-PKC immunoreactivities increased by 146%, in the putamen. There were no differences in the beta-I or gamma-PKC immunoreactivities in the putamen between HD and controls. These results suggest the differential localization of four PKC subspecies in human striatum and the involvement of four subspecies in different aspects of HD pathophysiology.

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页码：303 / 306

页数：4

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