PLASMINOGEN ACTIVATION IN LESIONAL SKIN OF PEMPHIGUS-VULGARIS TYPE NEUMANN

被引:14
作者
REINARTZ, J
NAHER, H
MAI, H
KRAMER, MD
机构
[1] UNIV HEIDELBERG,INST IMMUNOL & SEROL,IMMUNPATHOL LAB,NEUENHEIMER FELD 305,W-6900 HEIDELBERG,GERMANY
[2] UNIV HEIDELBERG,HAUTKLIN,W-6900 HEIDELBERG,GERMANY
关键词
PEMPHIGUS; SKIN BLISTER FLUID; PLASMINOGEN ACTIVATORS; PLASMIN ACTIVITY;
D O I
10.1007/BF00373352
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Zymographic and immunological studies revealed that primarily tissue-type plasminogen activator and to a lesser extent urokinase-type plasminogen activator were present in fluids of pemphigus vulgaris (type Neumann) skin blisters. Furthermore, plasmin activity was detected in pemphigus blister fluids using chromogenic peptide substrate assays. In pemphigus, but not in control, suction blister fluids plasmin/alpha2-antiplasmin and plasmin/alpha2-macroglobulin complexes were found by immunoprecipitation or by testing in immunoassays after fractionation by molecular-sieve chromatography. Plasmin activity, detected by a low molecular weight chromogenic peptide assay, was ascribed to plasmin/alpha2-macroglobulin complexes. Since formation of plasmin/inhibitor complexes requires active plasmin, the finding indicates previous activation of plasminogen in pemphigus lesions.
引用
收藏
页码:432 / 439
页数:8
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