RHODIUM-MEDIATED INSERTION OF CF3-SUBSTITUTED CARBENOID INTO O-H - AN EFFICIENT METHOD FOR THE SYNTHESIS OF ALPHA-TRIFLUOROMETHYLATED ALKOXYACETIC AND ARYLOXYACETIC ACID-DERIVATIVES

被引：49

作者：

SHI, GQ

CAO, ZY

CAI, WL

机构：

[1] Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Academia Sinica, 200032 Shanghai

来源：

TETRAHEDRON | 1995年 / 51卷 / 17期

关键词：

D O I：

10.1016/0040-4020(95)98698-H

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

CF3-substituted diazo compound 2 undergoes a facile rhodium carbenoid mediated O-H insertion reaction with a variety of alcohols and phenols to afford the title compounds in good yield. Use of the title compounds as synthetic precursors for other fluorinated molecules is exemplified by the transformation of the product 3b, into beta, beta-difluoro-alpha-ketoester 5 and alpha-hydroxyketone 8.

引用

页码：5011 / 5018

页数：8

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