INDUCTION OF TRANSPLANTATION RESISTANCE TO ROUS SARCOMA ISOGRAFT BY AVIAN LEUKOSIS VIRUS

Avian leukosis virus (ALV) particles were shown to be capable of inducing the production of transplantation antigens(s) that cross react immunologically with Rous sarcoma virus (RSV) specific TSTA. Mice injected with high doses of avian leukosis virus or ALV-transformed chicken myeloblasts were resistant to isografts of tumors induced by Rous sarcoma virus. It was found that a single ALV-injection into newborn mice was sufficient to induce transplantation resistance whereas the ALV particles themselves seemed not to be capable of transferring transplantation antigen. These results suggested that infection of mouse cells by ALV may be a requisite for the induction of tumor-specific transplantation antigens and subsequent immunity to the Rous sarcoma isografts. © 1969.