SYNTHESIS OF METHYL (-)-HOMOGABACULINATE AND A CARBA ANALOG OF 5-ENOLPYRUVYLSHIKIMIC ACID

被引：20

作者：

CAMPBELL, MM ^{[1
]}

SAINSBURY, M ^{[1
]}

SEARLE, PA ^{[1
]}

DAVIES, GM ^{[1
]}

机构：

[1] ICI PLC,PHARMACEUT,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)79846-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of (+/-)-3-[1-carboxy-3-alpha-4-alpha-dihydroxycyclohex-1-en-5-beta-yl]-2-methylenepropionic acid, a carba analogue of 5-enolpyruvylshikimic acid from methyl (+/-)-homogabaculinate is described. In addition, both enantiomers of methyl homogabaculinate have been obtained from the Diels Alder reaction of 1-tert-butoxy-carbonyl-1,2-dihydropyridine and the N-acryloyl derivative of Oppolzer's bomane 10,2-sultam.

引用

页码：3181 / 3184

页数：4

共 10 条

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