HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY SIMULTANEOUS QUANTITATION OF KETOPROFEN AND PARABENS IN A COMMERCIAL GEL FORMULATION

被引：17

作者：

MANNUCCI, C

BERTINI, J

COCCHINI, A

PERICO, A

SALVAGNINI, F

TRIOLO, A

机构：

[1] Analytical Research Department, A. Menarini Industrie Farmaceutiche Riunite S.R.L., Firenze

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1992年 / 15卷 / 02期

关键词：

D O I：

10.1080/10826079208017173

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and rapid procedure for quantitation of Ketoprofen and parabens simultaneously in a commercial gel formulation by reversed phase high performance liquid chromatography was developed. The chromatographic analysis has been undertaken on a Hypersil ODS column by using a solvent- mixture composed of acetonitrile-potassium dihydrogenphosphate buffer (pH = 3.0) (40:60, v/v) isocratically with a U.V. detection at 254 nm. Ketoprofen related impurities and hydrolysis product of parabens are well resolved in these conditions and the method can be applied to quality control analysis of Ketoprofen and parabens in gel formulation.

引用

页码：327 / 335

页数：9

共 9 条

[1]

BECHELLI P, 1980, POLICLINICO SEZ MED, P3

[2]

BRODGEN RN, 1974, DRUGS, V8, P168

[3]

CANUTI M, 1981, GIORNALE IT RIC C S7, V303, P81

[4]

GRAHAME R, 1976, SCAND J RHEUMATOL, V14, P133

[5]

KRAUS A, 1985, REV INVEST CLIN, V37, P153

[6] PURITY ASSAY OF KETOPROFEN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

PIETTA, P ;

MANERA, E ;

CEVA, P .

JOURNAL OF CHROMATOGRAPHY, 1987, 387 :525-527

[7] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF KETOPROFEN DEGRADATION PRODUCTS [J].

PIETTA, P ;

MANERA, E ;

CEVA, P .

JOURNAL OF CHROMATOGRAPHY, 1987, 390 (02) :454-457

[8]

Vitali G, 1980, Clin Ter, V94, P257

[9]

[No title captured]

← 1 →