SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME 1-SUBSTITUTED 3-PYRROLIDINYLUREAS

被引：8

作者：

HELSLEY, GC

FRANKO, BV

WELSTEAD, WJ

LUNSFORD, CD

机构：

[1] Research Laboratories, A. H. Robins company, Inc., Richmond, Virginia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 05期

关键词：

D O I：

10.1021/jm00311a027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1-substiuted 3-pyrrolidinylureas was synthesized and evaluated for pharmacologic activity. Some of the activities observed were CNS depressant, antiarrhythmic, local anesthetic, and hypoglycemie. © 1968, American Chemical Society. All rights reserved.

引用

页码：1034 / &

共 8 条

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GOGERTY, J
HOULIHAN, WJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (04) : 636 - &
[2] The preparation of ureas
Buck, JS
Ferry, CW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1936, 58 : 854 - 854
[3] DERIVATIVES OF 3-PYRROLIDINOLS .3. THE CHEMISTRY, PHARMACOLOGY, AND TOXICOLOGY OF SOME N-SUBSTITUTED-3-PYRROLIDYL ALPHA-SUBSTITUTED PHENYLACETATES
FRANKO, BV
LUNSFORD, CD
[J]. JOURNAL OF MEDICINAL & PHARMACEUTICAL CHEMISTRY, 1960, 2 (05): : 523 - 540
[4] HAACK E, 1955, Patent No. 9688
[5] HELSLEY GC, 1967, Patent No. 3316276
[6] A NEW GROUP OF ANTIFIBRILLANTS . N-(OMEGA-AMINOALKYL)PHTHALIMIDES
HIDEG, K
HANKOVSZ.HO
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (02) : 257 - &
[7] AMINOALKYLINDOLES WITH CENTRAL NERVOUS SYSTEM ACTIVITY
WELSTEAD, WJ
DAVANZO, JP
HELSLEY, GC
LUNSFORD, CD
TAYLOR, CR
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) : 1015 - &
[8] WINBURY MM, 1957, ACTA PHYSIOL PHARM N, V5, P468

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