PHENCYCLIDINE INCREASES EXTRACELLULAR DOPAMINE METABOLITES IN RAT MEDIAL FRONTAL-CORTEX AS MEASURED BY INVIVO DIALYSIS

被引：41

作者：

TANII, Y

NISHIKAWA, T

UMINO, A

TAKAHASHI, K

机构：

[1] NCNP,NATL INST NEUROSCI,DIV MENTAL DISORDER RES,4-1-1 OGAWA HIGASHI,TOKYO 187,JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV,FAC MED,DEPT NEUROPSYCHIAT,SUGITANI,TOYAMA 93001,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 2-3期

关键词：

Dopamine metabolism; In vivo dialysis; Medial prefrontal cortex; Phencyclidine; Tetrodotoxin;

D O I：

10.1016/0304-3940(90)90223-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An acute intraperitoneal injection of phencyclidine (PCP) caused a tetrodotoxin-reversible increase in extracellular release of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the dialysates from the medial frontal cortex of the rat. Moreover, there was an increase in the tissue content of DOPAC and HVA with acceleration of dopamine (DA), but not noradrenaline, utilization in the cortical area after systemic administration of PCP. These results suggest that PCP facilitates DA metabolism in the medial frontal cortex by increasing impulse flow in the DA neurons projecting to the prefrontal region. © 1990.

引用

页码：318 / 323

页数：6

共 21 条

[1]

BALSTER RL, 1987, PSYCHOPHARMACOLOGY 3, P1573

[2]

BANNON MJ, 1983, PHARMACOL REV, V35, P53

[3] HOMOVANILLIC-ACID IN RAT CAUDATE AND PREFRONTAL CORTEX FOLLOWING PHENCYCLIDINE AND AMPHETAMINE [J].