SPECT IMAGING OF DOPAMINE D2-RECEPTORS WITH I-123 IBZM - INITIAL EXPERIENCE IN CONTROLS AND PATIENTS WITH PARKINSONS SYNDROME AND WILSONS-DISEASE

被引：86

作者：

TATSCH, K

SCHWARZ, J

OERTEL, WH

KIRSCH, CM

机构：

[1] Division of Nuclear Medicine, Department of Radiology

[2] Division of Nuclear Medicine, Department of Neurology, Klinikum Grosshadern, University of Munich, Munich 70, 8000

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1991年 / 12卷 / 08期

关键词：

D O I：

10.1097/00006231-199108000-00005

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

I-123-(S-)-2-hydroxy-3-iodo-6-methoxy-N[(1-ethyl-2-pyrrolidinyl) methyl]-benzamide (I-123-IBZM) is a highly selective CNS D2 dopamine receptor ligand suitable for SPECT. This study reports on IBZM-SPECT findings in 60 patients including eight controls and 52 patients presenting with disorders of the dopaminergic system, including idiopathic Parkinson's syndrome (IPS) (n = 18), Parkinson's syndromes of other aetiology (PS) (n = 24) and Wilson's disease (n = 10). SPECT was performed 2 h p.i. of 185 MBq I-123-IBZM. For semiquantitative evaluation basal ganglia to frontal cortex ratios (BG/FC ratios) were calculated. In controls BG/FC ratios of 1.55 +/- 0.05 S.D. were observed. Findings in IPS patients (BG/FC ratio: 1.51 +/- 0.05) were not different from controls. In PS patients striatal IBZM binding (BG/FC ratio: 1.35 +/- 0.11) was significantly (P < 0.001) lower compared to the control and IPS groups. Asymptomatic patients with Wilson's disease presented normal IBZM binding. In those with neurologic symptoms IBZM fixation was markedly reduced. IBZM-SPECT has shown to be a suitable means for in vivo imaging of striatal dopamine D2 receptors in controls and various disorders of the dopaminergic system. Our preliminary data suggest that IBZM-SPECT is potentially useful for discriminating between IPS and PS (sensitivity: 100%; specificity: 83%). In patients with Wilson's disease IBZM accumulation seems to correlate with the presence of neurologic symptoms.

引用

页码：699 / 707

页数：9

共 13 条

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