EFFECT OF PHOTOSENSITIZERS IN CHEMICAL AND BIOLOGICAL PROCESSES - THE MTO MECHANISM IN PHOTODYNAMIC THERAPY

被引：36

作者：

GAL, D

机构：

[1] Central Research Institute for Chemistry, the Hungarian Academy of Sciences, H-1525 Budapest

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90850-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is suggested that in the course of the application of photosensitizers irradiated for cancer therapy a real competition occurs between the singlet oxygen mediated effects and the interactions between the triplet photosensitizers and doublet radicals formed in tumor cells while processes between photosensitizer radicals and molecules are negligible. This hypothesis is strongly supported by experimental findings and reveals a novel approach for the synthesis of new photosensitizers. © 1992.

引用

页码：1032 / 1036

页数：5

共 24 条

[1] THE TRIPLET AND RADICAL SPECIES OF HEMATOPORPHYRIN AND SOME OF ITS DERIVATIVES [J].