THE ISOLATION AND CHARACTERIZATION OF RABBIT MOTILIN PRECURSOR CDNA

被引：27

作者：

BANFIELD, DK

MACGILLIVRAY, RTA

BROWN, JC

MCINTOSH, CHS

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PHYSIOL,MRC,REGULATORY PEPTIDE GRP,VANCOUVER V6T 1Z3,BC,CANADA

[2] UNIV BRITISH COLUMBIA,DEPT BIOCHEM,VANCOUVER V6T 1W5,BC,CANADA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1131卷 / 03期

关键词：

MOTILIN ASSOCIATED PROTEIN; CDNA; (RABBIT);

D O I：

10.1016/0167-4781(92)90038-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cDNA sequence of rabbit motilin precursor has been determined. The predicted amino acid sequence indicates that the precursor consists of 133 amino acids and includes a 25 amino acid signal peptide followed by the 22 amino acid motilin sequence and an 86 amino acid motilin associated peptide (MAP). As in the human and procine precursors, two lysine residues follow motilin in the rabbit sequence. Rabbit motilin shares 64% amino acid sequence identity with human and porcine motilin, and all amino acid substitutions represent conservative changes. Amino acid sequence alignments of the rabbit, human and porcine MAP sequences suggest three functional/structural motifs corresponding to a putative endoproteinase recognition site, a putative PEST site and a potential posttranslational processing recognition element.

引用

页码：341 / 344

页数：4

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