MYELODYSPLASIA AND ACUTE MEGAKARYOBLASTIC LEUKEMIA IN DOWNS-SYNDROME

被引：120

作者：

ZIPURSKY, A

THORNER, P

DEHARVEN, E

CHRISTENSEN, H

DOYLE, J

机构：

[1] UNIV TORONTO,DEPT PATHOL,TORONTO M5S 1A1,ONTARIO,CANADA

[2] HOSP SICK CHILDREN,DEPT PEDIAT,DIV HEMATOL ONCOL,TORONTO M5G 1X8,ONTARIO,CANADA

[3] HOSP SICK CHILDREN,DEPT PATHOL,TORONTO M5G 1X8,ONTARIO,CANADA

来源：

LEUKEMIA RESEARCH | 1994年 / 18卷 / 03期

关键词：

MEGAKARYOBLASTS; MEGAKARYOBLASTIC LEUKEMIA; MYELODYSPLASIA; DOWNS SYNDROME;

D O I：

10.1016/0145-2126(94)90111-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this report we describe the clinical and hematologic features of 23 cases of myelodysplasia (MDS) or acute megakaryoblastic leukemia (AMKL) occurring in Down's syndrome. MDS was characterized by thrombocytopenia, abnormal megakaryocytopoiesis, megakaryoblasts (<30%) in the marrow and abnormal karyotype, the most common of which was trisomy 8, found in 7/15 patients with MDS. Three of five patients achieved a complete remission with low dose cytosine arabinoside, vincristine and retinyl palmitate. The high cure rate and the distinctive features of the leukemic process in these cases suggest that this type of MDS and AMKL are unique to patients with Down's syndrome.

引用

页码：163 / 171

页数：9

共 32 条

[1] PROPOSALS FOR THE CLASSIFICATION OF THE MYELODYSPLASTIC SYNDROMES [J].

BENNETT, JM ;

CATOVSKY, D ;

DANIEL, MT ;

FLANDRIN, G ;

GALTON, DAG ;

GRALNICK, HR ;

SULTAN, C .

BRITISH JOURNAL OF HAEMATOLOGY, 1982, 51 (02) :189-199

[2] LEUKEMIA OF PLATELET PRECURSORS - DIVERSE FEATURES IN 4 CASES [J].

BEVAN, D ;

ROSE, M ;

GREAVES, M .

BRITISH JOURNAL OF HAEMATOLOGY, 1982, 51 (01) :147-164

[3] ACUTE-LEUKEMIA CHARACTERIZED BY TRISOMY-8 IN DOWNS-SYNDROME [J].

BROOMHEAD, AF ;

KWAN, YL ;

ZELL, NA ;

LAMPOTANG, PRL ;

HUGHES, DOG .

PATHOLOGY, 1985, 17 (01) :111-114

[4]

CAIRNEY AEL, 1986, BRIT J HAEMATOL, V63, P541

[5]

CARROLL A, 1991, BLOOD, V78, P748

[6]

DEBILI N, 1989, LEUKEMIA, V3, P669

[7] DOUBLE LABELING OF CELL-SURFACE ANTIGENS WITH COLLOIDAL GOLD MARKERS [J].

DEHARVEN, E ;

SOLIGO, D ;

CHRISTENSEN, H .

HISTOCHEMICAL JOURNAL, 1990, 22 (01) :18-23

[8]

DOYLE JD, UNPUB

[9] ULTRASTRUCTURAL AND ULTRACYTOCHEMICAL DIFFERENCES BETWEEN TRANSIENT MYELOPROLIFERATIVE DISORDER AND MEGAKARYOBLASTIC LEUKEMIA IN DOWNS-SYNDROME [J].

EGUCHI, M ;

SAKAKIBARA, H ;

SUDA, J ;

OZAWA, T ;

HAYASHI, Y ;

SATO, T ;

KOJIMA, S ;

FURUKAWA, T .

BRITISH JOURNAL OF HAEMATOLOGY, 1989, 73 (03) :315-322

[10]

HAYASHI Y, 1988, BLOOD, V72, P15

← 1 2 3 4 →