ONTOGENY OF BEHAVIORAL SENSITIZATION IN THE RAT - EFFECTS OF DIRECT AND INDIRECT DOPAMINE AGONISTS

被引:36
作者
MCDOUGALL, SA [1 ]
DUKE, MA [1 ]
BOLANOS, CA [1 ]
CRAWFORD, CA [1 ]
机构
[1] UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR,INST NEUROPSYCHIAT,LOS ANGELES,CA 90024
关键词
BEHAVIORAL SENSITIZATION; AMPHETAMINE; NPA; ONTOGENY; RAT;
D O I
10.1007/BF02247482
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the present study, the abilities of NPA (a direct DA receptor agonist) and amphetamine (an indirect DA receptor agonist) to induce short- and long-term behavioral sensitization were assessed in 11- and 17-day-old rats (age at initial injection). Rats were injected on 4 consecutive days with amphetamine (1.0, 2.5, or 5.0 mg/kg), NPA (1.0 mg/kg), or saline. A final test day occurred either 2 days (experiment 1) or 8 days (experiment 2) later. On the test day, rats given successive agonist injections received a single injection of the same agonist again; whereas rats given successive saline injections received either amphetamine or NPA for the first time. Five minutes after injection, locomotor activity (line-crosses), stereotyped sniffng, and vertical activity were measured during a 30-min testing session. The results showed that 11- and 17-day-old rats exhibited behavioral sensitization when tested with NPA or amphetamine after a 2-day interval. In contrast, neither NPA nor amphetamine was able to sensitize the behaviors of preweanling rats when measured 8 days after initial drug treatments. Therefore, these results show that both direct and indirect DA agonists are able to induce short-term behavioral sensitization in preweanling rats, but that the mechanisms responsible for mediating long-term behavioral sensitization have not yet matured.
引用
收藏
页码:483 / 490
页数:8
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