HYDRATION OF RED-CELLS IN ALPHA-THALASSEMIA AND BETA-THALASSEMIA DIFFERS - A USEFUL APPROACH TO DISTINGUISH BETWEEN THESE RED-CELL PHENOTYPES

被引:19
作者
BUNYARATVEJ, A
FUCHAROEN, S
GREENBAUM, A
MOHANDAS, N
机构
[1] UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB,DIV LIFE SCI,BERKELEY,CA 94720
[2] MAHIDOL UNIV,RAMATHIBODI HOSP,DEPT PATHOL,BANGKOK 10700,THAILAND
[3] MAHIDOL UNIV,FAC MED,CTR THALALASSEMIA,BANGKOK,THAILAND
[4] MILES DIAGNOST,TARRYTOWN,NY
关键词
CELL HEMOGLOBIN CONCENTRATION; CELL VOLUME; HEMOGLOBINOPATHIES; RED CELL INDEXES; RED CELLS; THALASSEMIA;
D O I
10.1093/ajcp/102.2.217
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Differences in the pathobiologic features of alpha and beta thalassemic red cells include differing derangements in the ability of these cells to regulate their volume. To explore differences in cell hydration in these two red cell phenotypes, heterogeneity in hemoglobin concentration of individual red cells was quantitated. Red cells from 91 patients with alpha thalassemia (hemoglobin H disease) and 69 patients with beta thalassemia of the genotype beta-thal zero/Hb E were analyzed. Marked differences between these thalassemias were noted in the heterogeneity of hemoglobin concentration among individual cells. Decreased cell hemoglobin concentration and increased cell hydration were features of alpha-thalassemic blood samples, whereas both decreased and increased cell hemoglobin concentration as a result of cell hydration and dehydration, respectively, were features of beta-thalassemic blood samples. The documented differences in the hemoglobin concentration distributions should prove useful in distinguishing between the two thalassemic phenotypes.
引用
收藏
页码:217 / 222
页数:6
相关论文
共 16 条
[1]   IMPROVED CLASSIFICATION OF ANEMIAS BY MCV AND RDW [J].
BESSMAN, JD ;
GILMER, PR ;
GARDNER, FH .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1983, 80 (03) :322-326
[2]   QUANTITATIVE ANISOCYTOSIS AS A DISCRIMINANT BETWEEN IRON-DEFICIENCY AND THALASSEMIA MINOR [J].
BESSMAN, JD ;
FEINSTEIN, DI .
BLOOD, 1979, 53 (02) :288-293
[3]  
BOOKCHIN RM, 1988, BLOOD, V72, P1602
[4]  
BUNN HF, 1986, HEMOGLOBIN MOL GENET, P322
[5]   QUANTITATIVE CHANGES OF RED BLOOD-CELL SHAPES IN RELATION TO CLINICAL-FEATURES IN BETA-THALASSEMIA HBE DISEASE [J].
BUNYARATVEJ, A ;
SAHAPHONG, S ;
BHAMARAPRAVATI, N ;
WASI, P .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1985, 83 (05) :555-559
[6]   THALASSEMIA MINOR - ROUTINE ERYTHROCYTE MEASUREMENTS AND DIFFERENTIATION FROM IRON-DEFICIENCY [J].
JOHNSON, CS ;
TEGOS, C ;
BEUTLER, E .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1983, 80 (01) :31-36
[7]  
MOHANDAS N, 1989, BLOOD, V74, P442
[8]  
MOHANDAS N, 1986, BLOOD, V68, P506
[9]  
RACHMILEWITZ EA, 1985, CLIN HAEMATOL, V14, P163
[10]  
SCHRIER SL, 1992, BLOOD, V79, P1586