REPORTING OF ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICANCE ON CERVICAL SMEARS - IS IT SIGNIFICANT

被引：33

作者：

SELVAGGI, SM ^{[1
]}

HAEFNER, HK ^{[1
]}

机构：

[1] UNIV MICHIGAN,MED CTR,DEPT PATHOL,ANN ARBOR,MI 48109

来源：

DIAGNOSTIC CYTOPATHOLOGY | 1995年 / 13卷 / 04期

关键词：

CERVICAL CYTOLOGY; ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICANCE (ASCUS); ASCUS REPORT;

D O I：

10.1002/dc.2840130418

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A retrospective 7-mo study (June I, 1993-December 31, 1993) was performed to evaluate the significance of reporting atypical sguamous cells of undetermined significance (ASCUS) on cervical smears. During this period 114 (0.7%) of 17,330 smears were diagnosed as ASCUS, 62 of which resulted in either follow-up cervical biopsies and/or endocervical curettages (61%) or repeat smears (39%), and form the basis of this study. Tissue specimens (38 cases) were negative in 24 cases (63%) and were positive in 14 cases (37%). Of the positive specimens there were 9 low grade squamous intraepithelial lesions (LSIL) and 5 high grade squamous intraepithelial lesions (HSIL). Repeat smears (24 cases) were negative in 19 cases (79%) and were persistent for a lesion in 5 cases (21%). The persistent lesions consisted of 2 ASCUS and 3 LSIL. Overall, of the 62 cases, 43 (69%) were negative and 19 (31%) showed a lesion on follow-up tissue specimens or smears. Of the 62 cases, ASCUS diagnoses included cellular changes suggestive of human papillomavirus infection in 17 (27%) cases, nondiagnostic cellular changes in 16 (26%) cases, atypical squamous metaplasia vs. a squamous intraepithelial lesion (SIL) in 15 (24%) cases, inflammatory cell changes vs. a LSIL in 5 (8%) cases, 2 of which contained candida, and atrophic cellular changes in 1 (2%) case. In the remaining 8 (13%) cases, proper cytologic analysis was hampered by partially obscuring acute inflammation (3 cases) and low cellularity (5 cases). The results of this study would indicate that the reporting of ASCUS on cervical smears does lead to the detection of SILs in a significant number of cases (31% in this study). Therefore, further evaluation of the patient is suggested. (C) 1995 Wiley-Liss, Inc.

引用

页码：352 / 356

页数：5

共 16 条

[1] Melamed MR, Flehinger BJ, Non‐diagnostic squamous atypia in cervico‐vaginal cytology as a risk factor for early neoplasia, Acta Cytol, 20, pp. 108-110, (1976)
[2] Patton SF, Diagnostic cytopathology of the uterine cervix. Monographs in clinical cytology, (1978)
[3] The revised Bethesda System for reporting cervical/vaginal cytologic diagnoses: report of the 1991 Bethesda Workshop, Acta Cytol, 36, pp. 273-276, (1992)
[4] Kurman RJ, Solomon D, The Bethesda System for reporting cervical/vaginal cytologic diagnoses: definitions, criteria and explanatory notes for terminology and specimen adequacy, (1994)
[5] Patton SF, Diagnostic cytopathology of the uterine cervix. Monographs in clinical cytology, (1978)
[6] Darnell Jones DE, Creasman WT, Dombroski RA, Lentz SS, Waeltz JL, Evaluation of the atypical Pap smear, American Journal of Obstetrics and Gynecology, 157, pp. 544-549, (1987)
[7] Davis GL, Hernandez E, Davis JL, Miyazawa K, Atypical squamous cells in Papanicolaou smears, Obstet Gynecol, 69, pp. 43-46, (1987)
[8] Sandmire HF, Austin SD, Bechtel RC, Experience with 40,000 Papanicolaou smears, Obstet Gynecol, 48, pp. 56-60, (1976)
[9] Nyirjesy I, Atypical or suspicious cervical smears: an aggressive diagnostic approach, JAMA, 222, pp. 691-693, (1972)
[10] Cecchini S, Lossa A, Ciatto S, Et al., Routine colposcopic survey of patients with squamous atypia: a method for identifying cases with false‐negative smears, Acta Cytol, 34, pp. 778-780, (1990)

← 1 2 →