ANTIBIOTIC SUSCEPTIBILITY AND OUTER-MEMBRANE PROTEINS OF CLINICAL XANTHOMONAS-MALTOPHILIA ISOLATES

被引：36

作者：

CULLMANN, W ^{[1
]}

机构：

[1] RUHR UNIV BOCHUM,DEPT MED MICROBIOL & IMMUNOL,W-4630 BOCHUM,GERMANY

来源：

CHEMOTHERAPY | 1991年 / 37卷 / 04期

关键词：

XANTHOMONAS-MALTOPHILIA; ANTIMICROBIAL SUSCEPTIBILITY; OUTER MEMBRANE PROTEINS;

D O I：

10.1159/000238862

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty clinical Xanthomonas maltophilia isolates were studied for their susceptibility to various antibiotics and for their outer membrane protein profiles and compared to Pseudomonas aeruginosa isolates. Among the antibiotics studied, fleroxacin and ciprofloxacin exhibited the greatest activity (MIC90 4-mu-g/ml). All the X. maltophilia isolates exhibited similar outer membrane protein profiles with 40, 23 and 21 major proteins, whereas the outer membrane of P. aeruginosa revealed at least 7 major outer membrane proteins, as is known from the literature. Thus, it is assumed that the outer membrane profile of X. maltophilia contributes to the resistance of this nosocomial pathogen to most antibiotics.

引用

页码：246 / 250

页数：5

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