THE EFFECT OF AN ANGIOTENSIN CONVERTING-ENZYME-INHIBITOR, RAMIPRIL, ON BRONCHIAL RESPONSES TO INHALED HISTAMINE AND BRADYKININ IN ASTHMATIC SUBJECTS

被引：54

作者：

DIXON, CMS ^{[1
]}

FULLER, RW ^{[1
]}

BARNES, PJ ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH, DEPT CLIN PHARMACOL, LONDON W12 0HS, ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1987年 / 23卷 / 01期

关键词：

D O I：

10.1111/j.1365-2125.1987.tb03015.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of a potent inhibitor of angiotensin-converting enzyme, ramipril, was studied on both inhaled histamine and bradykinin-induced bronchoconstriction in six male, normotensive, mild asthmatic subjects. Oral administration of 10 mg ramipril caused no change in lung function or airway reactivity to inhaled histamine or bradykinin despite achieving adequate reduction in angiontensin-converting enzyme activity.

引用

页码：91 / 93

页数：3

共 10 条

[1] A NEW METHOD FOR COMPUTER-ASSISTED DETERMINATION OF AIRWAYS RESISTANCE
CHOWIENCZYK, PJ
REES, PJ
PAYNE, J
CLARK, TJH
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1981, 50 (03) : 672 - 678
[2] ECKERT HG, 1984, DRUG RES, V34, P1448
[3] FULLER RW, 1986, AM REV RESPIR DIS, V133, pA91
[4] HOWARD P, 1987, BR J CLIN PHARM
[5] MACGUIRE GA, 1985, ANN CLIN BIOCHEM, V22, P204
[6] REGOLI D, 1980, PHARMACOL REV, V32, P1
[7] SEMPLE PF, 1986, NEW ENGL J MED, V314, P61
[8] SESKO S, 1985, ARCH INTERN MED, V145, P1524
[9] SIMONSSON BG, 1973, RESPIRATION, V30, P378, DOI 10.1159/000193051
[10] WITTE PU, 1984, ARZNEIMITTEL-FORSCH, V34-2, P1448

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