EVALUATION OF DIFFERENT PACKINGS FOR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF ALKYL LYSOPHOSPHOLIPIDS

被引：7

作者：

COENE, J ^{[1
]}

GHIJS, M ^{[1
]}

VANDENEECKHOUT, E ^{[1
]}

VANDENBOSSCHE, W ^{[1
]}

SANDRA, P ^{[1
]}

机构：

[1] STATE UNIV GHENT,ORGAN CHEM LAB,B-9000 GHENT,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 553卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(01)88499-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The analysis of the alkyl lysophospholipid 1-octadecyl-2-O-methyl-D,L-glycero-3-phosphorylcholine is currently under investigation because of its anticancer activity. The chromatographic behaviour of this compound and its 1-hexadecyl-2-O-methyl-D,L-glycero-3-phosphorylcholine homologue, which is used as an internal standard for pharmacokinetic studies, on various liquid chromatography packings gave rise to many problems. The retention and elution characteristics of both ether phospholipids were studied on silica, straight polyethyleneglycol-coated silica, reversed-phase materials, base-deactivated reversed-phase silica and polymeric resins.

引用

页码：285 / 297

页数：13

共 18 条

[1]

ASCAH TL, 1989, PITTSBURGH C ATLANTA, P1450

[2] SILANOPHILIC INTERACTIONS IN REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

BAYER, E ;

PAULUS, A .

JOURNAL OF CHROMATOGRAPHY, 1987, 400 :1-4

[3]

BERDEL WE, 1985, PHOSPHOLIPIDS CELLUL, V2, P41

[4] SURFACE SILANOLS IN SILICA-BONDED HYDROCARBONACEOUS STATIONARY PHASES .2. IRREGULAR RETENTION BEHAVIOR AND EFFECT OF SILANOL MASKING [J].

BIJ, KE ;

HORVATH, C ;

MELANDER, WR ;

NAHUM, A .

JOURNAL OF CHROMATOGRAPHY, 1981, 203 (JAN) :65-84

[5]

Christie WW., 1982, LIPID ANAL

[6] EVALUATION OF DENSITOMETRIC QUANTITATION OF ETHER PHOSPHOLIPIDS BY HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY [J].

COENE, I ;

RAMOS, ME ;

VANDENECKHOUT, E ;

SANDRA, P ;

VANDENBOSSCHE, W .

CHROMATOGRAPHIA, 1990, 30 (7-8) :414-420

[7]

COENE J, 1990 ABSTR PITTSB C, P835

[8]

COX GB, 1987, J CHROMATOGR, V381, P315

[9]

GHIJS M, 1990, INT S CHROMATOGRAPHY

[10]

JOST W, 1990, BIOANAL TECH MAY, P46

← 1 2 →