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SIGNALING PROPERTIES OF LYSOPHOSPHATIDIC ACID

被引：115
作者：
DURIEUX, ME
LYNCH, KR
机构：
[1] University of Virginia, Charlottesville
[2] University of Virginia, Charlottesville
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1993年 / 14卷 / 06期
关键词：
D O I：
10.1016/0165-6147(93)90021-B
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Lysophosphatidic acid (LPA) is the simplest natural phospholipid, primarily known as a membrane component and metabolic intermediate. However, a remarkable variety of biological effects of this compound have come to light, seemingly pointing to an additional role for LPA as a signalling molecule. In this review, Marcel Durieux and Kevin Lynch integrate the recent information that indicates that LPA could be an intercellular messenger, possibly acting through a G protein-coupled receptor, and with a role in cell growth and motility.
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页码：249 / 254
页数：6
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