THE INTERLEUKIN-1 RECEPTOR ANTAGONIST IS A PARTIAL AGONIST OF PROSTAGLANDIN SYNTHESIS BY HUMAN DECIDUAL CELLS

被引:10
作者
COLE, OF [1 ]
SULLIVAN, MHF [1 ]
ELDER, MG [1 ]
机构
[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,INST OBSTET & GYNAECOL,LONDON W12 0NN,ENGLAND
来源
PROSTAGLANDINS | 1993年 / 46卷 / 06期
基金
英国惠康基金;
关键词
D O I
10.1016/0090-6980(93)90068-I
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In many systems the interleukin-1 receptor antagonist opposes the effects of interleukin-1 beta. We considered that it might block interleukin-1 beta-stimulated prostaglandin production from human decidual cells. Very high levels of interleukin-1 receptor antagonist (>1000 pg/ml) had limited inhibitory effects on IL-1 beta-stimulated PGE2 synthesis, and lower levels of antagonist (<1000 pg/ml) increased the effects of IL-1 beta. Low concentrations of the antagonist alone (1-100pg/ml) increased basal PGE2 production, whereas higher levels (10-100 ng/ml) had less effect. It seems, therefore, that in human decidua the ''antagonist'' is more accurately described as a partial agonist. It has been suggested that the IL-1 receptor antagonist could be used to inhibit decidual prostaglandin synthesis and thereby prevent preterm labor, but this report shows that caution should be exercised before using the receptor antagonist.
引用
收藏
页码:493 / 498
页数:6
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