The effect of granulocyte-macrophage colony-stimulating factor on myeloid cells and its clinical applications

被引：35

作者：

Hill, ADK ^{[1
]}

Naama, HA ^{[1
]}

Calvano, SE ^{[1
]}

Daly, JM ^{[1
]}

机构：

[1] CORNELL UNIV, MED CTR, NEW YORK HOSP, DEPT SURG, NEW YORK, NY 10021 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1995年 / 58卷 / 06期

关键词：

hematopoietic cells; effector cells; neutropenia;

D O I：

10.1002/jlb.58.6.634

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. Clinical applications of GM-CSF include ameliorating chemotherapy-induced neutropenia and enhancing hematopoietic recovery after bone marrow transplantation. This review evaluates the effect of GM-CSF on myeloid cells and its clinical applications.

引用

页码：634 / 642

页数：9

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