TREATMENT OPTIONS FOR OSTEOPOROSIS

被引:10
作者
KHOSLA, S [1 ]
RIGGS, BL [1 ]
机构
[1] MAYO CLIN & MAYO FDN,DIV ENDOCRINOL METAB & INTERNAL MED,ROCHESTER,MN 55905
关键词
D O I
10.4065/70.10.978
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The number of women affected by postmenopausal osteoporosis is likely to continue to increase substantially as the population ages, Furthermore, the therapeutic options for such patients are likely to increase. In this brief review, we outline the use of the currently available medications for the management of osteoporosis-namely, estrogen, calcitonin, calcium, and vitamin D, In addition, me discuss the next generation of drugs that are likely to become available in the future-the bisphosphonates and estrogen analogues, As these options become available, the prevention and treatment of osteoporosis will become similar to the management of other common disorders such as hypertension or hyperlipidemia, in which the most appropriate medication may differ for individual patients, Thus, the treatment of osteoporosis is likely to evolve from a decision of whether to initiate estrogen replacement therapy to a more complex decision of the best agent to use for an individual patient.
引用
收藏
页码:978 / 982
页数:5
相关论文
共 17 条
[1]   RALOXIFENE (LY139481 HCL) PREVENTS BONE LOSS AND REDUCES SERUM-CHOLESTEROL WITHOUT CAUSING UTERINE HYPERTROPHY IN OVARIECTOMIZED RATS [J].
BLACK, LJ ;
SATO, M ;
ROWLEY, ER ;
MAGEE, DE ;
BEKELE, A ;
WILLIAMS, DC ;
CULLINAN, GJ ;
BENDELE, R ;
KAUFFMAN, RF ;
BENSCH, WR ;
FROLIK, CA ;
TERMINE, JD ;
BRYANT, HU .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (01) :63-69
[2]   BONE TURNOVER IN POSTMENOPAUSAL OSTEOPOROSIS - EFFECT OF CALCITONIN TREATMENT [J].
CIVITELLI, R ;
GONNELLI, S ;
ZACCHEI, F ;
BIGAZZI, S ;
VATTIMO, A ;
AVIOLI, LV ;
GENNARI, C .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (04) :1268-1274
[3]   THE USE OF ESTROGENS AND PROGESTINS AND THE RISK OF BREAST-CANCER IN POSTMENOPAUSAL WOMEN [J].
COLDITZ, GA ;
HANKINSON, SE ;
HUNTER, DJ ;
WILLETT, WC ;
MANSON, JE ;
STAMPFER, MJ ;
HENNEKENS, C ;
ROSNER, B ;
SPEIZER, FE .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (24) :1589-1593
[4]   METABOLIC EFFECTS OF SYNTHETIC CALCITRIOL (ROCALTROL) IN THE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS [J].
GALLAGHER, JC .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1990, 39 (04) :27-29
[5]   HORMONE-THERAPY TO PREVENT DISEASE AND PROLONG LIFE IN POSTMENOPAUSAL WOMEN [J].
GRADY, D ;
RUBIN, SM ;
PETITTI, DB ;
FOX, CS ;
BLACK, D ;
ETTINGER, B ;
ERNSTER, VL ;
CUMMINGS, SR .
ANNALS OF INTERNAL MEDICINE, 1992, 117 (12) :1016-1037
[6]  
Kleerekoper M, 1991, Osteoporos Int, V1, P155, DOI 10.1007/BF01625446
[7]   EFFECTS OF TAMOXIFEN ON BONE-MINERAL DENSITY IN POSTMENOPAUSAL WOMEN WITH BREAST-CANCER [J].
LOVE, RR ;
MAZESS, RB ;
BARDEN, HS ;
EPSTEIN, S ;
NEWCOMB, PA ;
JORDAN, VC ;
CARBONE, PP ;
DEMETS, DL .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (13) :852-856
[8]   TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS WITH TRANSDERMAL ESTROGEN [J].
LUFKIN, EG ;
WAHNER, HW ;
OFALLON, WM ;
HODGSON, SF ;
KOTOWICZ, MA ;
LANE, AW ;
JUDD, HL ;
CAPLAN, RH ;
RIGGS, BL .
ANNALS OF INTERNAL MEDICINE, 1992, 117 (01) :1-9
[9]   SLOW-RELEASE SODIUM-FLUORIDE IN THE MANAGEMENT OF POSTMENOPAUSAL OSTEOPOROSIS - A RANDOMIZED CONTROLLED TRIAL [J].
PAK, CYC ;
SAKHAEE, K ;
PIZIAK, V ;
PETERSON, RD ;
BRESLAU, NA ;
BOYD, P ;
POINDEXTER, JR ;
HERZOG, J ;
HEARDSAKHAEE, A ;
HAYNES, S ;
ADAMSHUET, B ;
REISCH, JS .
ANNALS OF INTERNAL MEDICINE, 1994, 120 (08) :625-632
[10]   EFFECT OF CALCIUM SUPPLEMENTATION ON BONE LOSS IN POSTMENOPAUSAL WOMEN [J].
REID, IR ;
AMES, RW ;
EVANS, MC ;
GAMBLE, GD ;
SHARPE, SJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1993, 328 (07) :460-464