CLEARANCE OF SERUM PSA AFTER OPEN SURGERY FOR BENIGN PROSTATIC HYPERTROPHY, RADICAL CYSTECTOMY, AND RADICAL PROSTATECTOMY

被引:21
作者
HAAB, F
MEULEMANS, A
BOCCONGIBOD, L
DAUGE, MC
DELMAS, V
BOCCONGIBOD, L
机构
[1] HOP BICHAT,UROL SERV,F-75018 PARIS,FRANCE
[2] HOP BICHAT,DEPT NUCL MED,F-75018 PARIS,FRANCE
[3] HOP BICHAT,DEPT PATHOL,F-75018 PARIS,FRANCE
[4] HOP TROUSSEAU,DEPT PATHOL,PARIS,FRANCE
关键词
PSA CLEARANCE; SURGERY; PROSTATE CANCER;
D O I
10.1002/pros.2990260609
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To study the clearance of serum prostate-specific antigen (PSA) after several types of prostatic tissue ablation. Methods: Serum PSA levels were measured (YANG Proscheck ultrasensitive assay) just before surgery, immediately after specimen removal, then twice weekly for 5 weeks or until it was undetectable (<0.05 ng/ml) in patients undergoing radical cystoprostatectomy for bladder cancer (n = 10), or radical prostatectomy for T1 T2 prostate cancer (n = 18) and daily for 6 days after open surgery for benign prostatic hypertrophy (BPH) (n = 10). Results: Open enucleation for BPH: the immediately postoperative PSA level was 6 times its preoperative value. It decreased following a monoexponential curve with a very short half-life of 0.55 +/- 0.39 days, range (0.14-1.3), reaching a value lower than the preoperative level in all cases, except one by day 3. After radical cystoprostatectomy: the decrease of serum PSA is monoexponential with a half life of 1.92 +/- 1.2 days (0.57-4.24) reaching undetectable level (<0.05 ng/ml) in all patients by day 21. After radical prostatectomy: 11/18 patients (61%) showed a one-component exponential decrease in PSA with a half-life of 2.5 +/- 1.33 days (range 0.97-4.6 days), and 7/18 showed a two-component exponential decrease with a first half-life of 0.94 +/- 0.8 days and a second of 7.62 +/- 6.35 days); 100% of the patients reached undetectable serum PSA by day 28 in the first group compared to 14.2% of the patients with a two component exponential decrease (P < 0.01). There was no difference between these groups as far as preoperative PSA levels and specimen pathology were concerned. Conclusion: Serum clearance of PSA after extirpative prostatic surgery is closely related to the type and indication of procedure used. Radical cystoprostatectomy is probably the best model in which to study the pharmacokinetics of PSA. (C) 1995 Wiley-Liss, Inc.
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收藏
页码:334 / 338
页数:5
相关论文
共 26 条
  • [1] BRAWER MK, 1989, WORLD J UROL, V7, P277
  • [2] Breul J., 1993, Journal of Urology, V149, p302A
  • [3] PROSTATE-SPECIFIC ANTIGENIC DOMAIN OF HUMAN-PROSTATE SPECIFIC ANTIGEN IDENTIFIED WITH MONOCLONAL-ANTIBODIES
    CHU, TM
    KAWINSKI, E
    HIBI, N
    CROGHAN, G
    WILEY, J
    KILLIAN, CS
    CORRAL, D
    [J]. JOURNAL OF UROLOGY, 1989, 141 (01) : 152 - 156
  • [4] PROSTATIC SPECIFIC ANTIGEN AND PROSTATIC ACID-PHOSPHATASE IN THE MONITORING AND STAGING OF PATIENTS WITH PROSTATIC-CANCER
    ERCOLE, CJ
    LANGE, PH
    MATHISEN, M
    CHIOU, RK
    REDDY, PK
    VESSELLA, RL
    [J]. JOURNAL OF UROLOGY, 1987, 138 (05) : 1181 - 1184
  • [5] GRAVES HCB, 1992, CLIN CHEM, V38, P735
  • [6] AN ANALYSIS OF URINARY PROSTATE SPECIFIC ANTIGEN BEFORE AND AFTER RADICAL PROSTATECTOMY - EVIDENCE FOR SECRETION OF PROSTATE SPECIFIC ANTIGEN BY THE PERIURETHRAL GLANDS
    IWAKIRI, J
    GRANDBOIS, K
    WEHNER, N
    GRAVES, HCB
    STAMEY, T
    [J]. JOURNAL OF UROLOGY, 1993, 149 (04) : 783 - 786
  • [7] EXTRAPROSTATIC LOCALIZATION OF PROSTATIC ACID-PHOSPHATASE AND PROSTATE-SPECIFIC ANTIGEN - DISTRIBUTION IN CLOACOGENIC GLANDULAR EPITHELIUM AND SEX-DEPENDENT EXPRESSION IN HUMAN ANAL GLAND
    KAMOSHIDA, S
    TSUTSUMI, Y
    [J]. HUMAN PATHOLOGY, 1990, 21 (11) : 1108 - 1111
  • [8] PROSTATE SPECIFIC ANTIGEN AND LOCAL RECURRENCE AFTER RADICAL PROSTATECTOMY
    LIGHTNER, DJ
    LANGE, PH
    REDDY, PK
    MOORE, L
    [J]. JOURNAL OF UROLOGY, 1990, 144 (04) : 921 - 926
  • [9] LILJA H, 1992, CANCER, V70, P230, DOI 10.1002/1097-0142(19920701)70:1+<230::AID-CNCR2820701310>3.0.CO
  • [10] 2-Y