fMRI of human somatosensory and cingulate cortex during painful electrical nerve stimulation

被引:95
作者
Davis, KD [1 ]
Wood, ML [1 ]
Crawley, AP [1 ]
Mikulis, DJ [1 ]
机构
[1] UNIV TORONTO,TORONTO HOSP,WESTERN DIV,DEPT MED IMAGING,TORONTO,ON M5T 2S8,CANADA
关键词
fMRI; SI; cingulate; cortex; pain;
D O I
10.1097/00001756-199512290-00077
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
FUNCTIONAL MRI (fMRI) can detect changes from resting levels of blood flow and oxygenation during task performance (i.e. activation). We used a simple electrical nerve stimulation technique together with fMRI to study pain processes in the human cortex. Images of the primary somatosensory (SI) and cingulate cortex (Cg) were obtained from subjects during stimulation at painful and non-painful intensities. Stimuli that evoked non-painful tingling sensations activated the contralateral SI but not Cg. Stimuli that evoked painful sensations activated both the contralateral SI and Cg. These data indicate that fMRI can detect pain-related changes in SI and Cg evoked by electrical stimulation of peripheral nerves. These findings add to the evidence for a role of SI and Cg in human pain processes and provide a simple method of stimulus delivery for its study.
引用
收藏
页码:321 / 325
页数:5
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