ANTIGENS OF MELANOCYTES AND MELANOMA

被引：16

作者：

LYNCH, SA

BOUCHARD, BN

VIJAYASARADHI, S

YUASA, H

HOUGHTON, AN

机构：

[1] MEM SLOAN KETTERING CANC CTR,IMMUNOL PROGRAM,NEW YORK,NY 10021

[2] MEM SLOAN KETTERING CANC CTR,DEPT MED,NEW YORK,NY 10021

[3] CORNELL UNIV,MED CTR,COLL MED,NEW YORK,NY 10021

来源：

CANCER AND METASTASIS REVIEWS | 1991年 / 10卷 / 02期

关键词：

MELANOCYTE; MELANOMA; DIFFERENTIATION; TRANSFORMATION; ANTIGEN;

D O I：

10.1007/BF00049411

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Melanoma is a valuable model to study phenotypic traits that are regulated during cell differentiation and malignant transformation. Melanoma cells display extensive phenotypic and antigenic heterogeneity. Studies of this attribute have provided insight into events that take place during normal melanocyte differentiation and give clues to traits that contribute to malignancy. It is possible that the phenotypic and genotypic heterogeneity present among melanoma cells within a single lesion includes a subset of cells with traits that favor tumor progression and metastasis. This review discusses the identification and characterization of antigens expressed by melanoma cells and their potential contribution to melanocyte differentiation and malignant transformation.

引用

页码：141 / 150

页数：10

共 38 条

[1] HETEROGENEITY IN SURFACE-ANTIGEN AND GLYCOPROTEIN EXPRESSION OF CELL-LINES DERIVED FROM DIFFERENT MELANOMA METASTASES OF THE SAME PATIENT - IMPLICATIONS FOR THE STUDY OF TUMOR-ANTIGENS [J].