THE PATHOGENESIS OF LEISHMANIA-AETHIOPICA INFECTION IN BALB/C MICE

被引：12

作者：

AKUFFO, HO ^{[1
]}

WALFORD, C ^{[1
]}

NILSEN, R ^{[1
]}

机构：

[1] UNIV BERGEN,INST INT HLTH,N-5014 BERGEN,NORWAY

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1990年 / 32卷 / 02期

关键词：

D O I：

10.1111/j.1365-3083.1990.tb02899.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A mouse model for L. aethiopica infection is described. BALB/c mice were unable to clear an infection with 1 × 107 promastigotes injected into the hind footpad. However, there was no ulceration of the lesion and no development of overt clinical symptoms after 203 days of infection. Spread of viable organisms was evident in the draining lymph node but not in the spleen or liver. The control of the infection was associated with the development of classical delayed hypersensitivity responses to phenolized promastigotes and appeared as a localized granulomatous infiltration. The infiltration had features of classical tuberculoid granulomas, but superimposed on it was a strong eosinophilic infiltration. The relevance of such cells though unclear is discussed. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：103 / 110

页数：8

共 11 条

[1]

AKUFFO HO, 1988, J IMMUNOL, V141, P2461

[2] INBRED MICE AS MODEL HOSTS FOR CUTANEOUS LEISHMANIASIS .1. RESISTANCE AND SUSCEPTIBILITY TO INFECTION WITH LEISHMANIA-BRAZILIENSIS, LEISHMANIA-MEXICANA, AND LEISHMANIA-AETHIOPICA [J].