A PHASE-I STUDY OF THE COMBINATION OF 2 HYPOXIC CELL RADIOSENSITIZERS, RO-03-8799 AND SR-2508 - TOXICITY AND PHARMACOKINETICS

被引：33

作者：

NEWMAN, HFV ^{[1
]}

BLEEHEN, NM ^{[1
]}

WORKMAN, P ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,SCH MED,DEPT CLIN ONCOL & RADIOTHERAPEUT,CAMBRIDGE CB2 2QH,ENGLAND

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1986年 / 12卷 / 07期

关键词：

D O I：

10.1016/0360-3016(86)90238-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1113 / 1116

页数：4

共 10 条

[1] PARTITION-COEFFICIENT AS A GUIDE TO THE DEVELOPMENT OF RADIOSENSITIZERS WHICH ARE LESS TOXIC THAN MISONIDAZOLE
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WORKMAN, P
[J]. RADIATION RESEARCH, 1980, 82 (01) : 171 - 190
[2] BROWN JM, 1981, INT J RAD ONCOL BIOL, V4, P659
[3] INITIAL REPORT OF THE PHASE-I TRIAL OF THE HYPOXIC CELL RADIOSENSITIZER SR-2508
COLEMAN, CN
URTASUN, RC
WASSERMAN, TH
HANCOCK, S
HARRIS, JW
HALSEY, J
HIRST, VK
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (09): : 1749 - 1753
[4] CELLULAR UPTAKE OF MISONIDAZOLE AND ANALOGS WITH ACIDIC OR BASIC FUNCTIONS
DENNIS, MF
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[J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1985, 47 (06) : 629 - 643
[5] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF THE NEW HYPOXIC CELL RADIOSENSITIZER, RO 03-8799, IN BIOLOGICAL SAMPLES
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LEE, A
GROVES, JK
[J]. JOURNAL OF CHROMATOGRAPHY, 1983, 273 (02): : 327 - 333
[6] A PHASE-I STUDY OF THE HYPOXIC CELL RADIOSENSITIZER RO-03-8799
ROBERTS, JT
BLEEHEN, NM
WORKMAN, P
WALTON, MI
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (09): : 1755 - 1758
[7] A CLINICAL PHASE-1 TOXICITY STUDY OF RO-03-8799 - PLASMA, URINE, TUMOR AND NORMAL BRAIN PHARMACOKINETICS
ROBERTS, JT
BLEEHEN, NM
WALTON, MI
WORKMAN, P
[J]. BRITISH JOURNAL OF RADIOLOGY, 1986, 59 (698) : 107 - 116
[8] THE CLINICAL-TESTING OF RO 03-8799 PHARMACOKINETICS, TOXICOLOGY, TISSUE AND TUMOR CONCENTRATIONS
SAUNDERS, MI
ANDERSON, PJ
BENNETT, MH
DISCHE, S
MINCHINTON, A
STRATFORD, MRL
TOTHILL, M
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (09): : 1759 - 1763
[9] Smithen C., 1980, RAD SENSITIZERS THEI, P22
[10] INVIVO TESTING OF A 2-NITROIMIDAZOLE RADIOSENSITIZER (RO-03-8799) USING REPEATED ADMINISTRATION
WILLIAMS, MV
DENEKAMP, J
MINCHINTON, AI
STRATFORD, MRL
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (3-4): : 477 - 481

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