PROSTAGLANDIN ANALOGS .9. SYNTHESIS OF A NEW CHEMICALLY AND METABOLICALLY STABLE PROSTACYCLIN ANALOG WITH HIGH AND LONG-LASTING ORAL ACTIVITY

被引：124

作者：

SKUBALLA, W ^{[1
]}

SCHILLINGER, E ^{[1
]}

STSTURZEBECHER, C ^{[1
]}

VORBRUGGEN, H ^{[1
]}

机构：

[1] SCHERING AG,RES LABS,BERGKAMEN,FED REP GER

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1986年 / 29卷 / 03期

关键词：

D O I：

10.1021/jm00153a001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：313 / 315

页数：3

共 16 条

[1]

HABEREY M, 1980, THERAPIEWOCHE, V30, P7860

[2] DIRECTED RESOLUTION OF ENANTIOMERS VIA LIQUID CHROMATOGRAPHY OF DIASTEREOMERIC DERIVATIVES .5. PREPARATIVE SCALE DIRECTED RESOLUTION OF ENANTIOMERIC CARBOXYLIC-ACIDS AND LACTONES VIA LIQUID-CHROMATOGRAPHY AND NEIGHBORING-GROUP ASSISTED HYDROLYSIS OF DIASTEREOMERIC AMIDES [J].

HELMCHEN, G ;

NILL, G ;

FLOCKERZI, D ;

YOUSSEF, MSK .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1979, 18 (01) :63-65

[3] DIRECTED RESOLUTION OF ENANTIOMERS VIA LIQUID-CHROMATOGRAPHY OF DIASTEREOMERIC DERIVATIVES .4. EXTREME LIQUID-CHROMATOGRAPHIC SEPARATION EFFECTS IN THE CASE OF DIASTEREOMERIC AMIDES CONTAINING POLAR SUBSTITUENTS [J].

HELMCHEN, G ;

NILL, G ;

FLOCKERZI, D ;

SCHUHLE, W ;

YOUSSEF, MSK .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1979, 18 (01) :62-63

[4]

KRAIS T, ADV PROSTAGLANDIN TH

[5]

KRAUSE W, 1984, DRUG METAB DISPOS, V12, P645

[6]

LEVINE PA, 1932, J BIOL CHEM, V98, P1

[7] OXAZOLINES .14. ASYMMETRIC SYNTHESIS OF R-DIALKYLACETIC AND S-DIALKYLACETIC ACIDS FROM A SINGLE CHIRAL OXAZOLINE [J].

MEYERS, AI ;

KNAUS, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (20) :6508-6510

[8] SYNTHESIS VIA 2-OXAZOLINES .4. ASYMMETRIC SYNTHESIS OF 2-METHYLALKANOIC ACIDS FROM A CHIRAL OXAZOLINE [J].

MEYERS, AI ;

KNAUS, G ;

KAMATA, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (01) :268-270

[9] ENZYME ISOLATED FROM ARTERIES TRANSFORMS PROSTAGLANDIN ENDOPEROXIDES TO AN UNSTABLE SUBSTANCE THAT INHIBITS PLATELET-AGGREGATION [J].

MONCADA, S ;

GRYGLEWSKI, R ;

BUNTING, S ;

VANE, JR .

NATURE, 1976, 263 (5579) :663-665

[10] PROSTACYCLIN-ANALOGS [J].

NICKOLSON, RC ;

TOWN, MH ;

VORBRUGGEN, H .

MEDICINAL RESEARCH REVIEWS, 1985, 5 (01) :1-53

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