EFFECTIVE INACTIVATION OF HUMAN-IMMUNODEFICIENCY-VIRUS WITH CHLORHEXIDINE ANTISEPTICS CONTAINING DETERGENTS AND ALCOHOL

被引：26

作者：

MONTEFIORI, DC

ROBINSON, WE

MODLISZEWSKI, A

MITCHELL, WM

机构：

[1] Department of Pathology, Vanderbilt University Medical School, Nashville

来源：

JOURNAL OF HOSPITAL INFECTION | 1990年 / 15卷 / 03期

关键词：

D O I：

10.1016/0195-6701(90)90036-N

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The antiseptics 4% chlorhexidine gluconate detergent formulation containing 4% isopropyl alcohol (Hibiclens/Hibiscrub) and 0·5% chlorhexidine gluconate in 70% isopropyl alcohol with emollients (Hibistat/ Hibisol) efficiently inactivated human immunodeficiency virus (HIV) produced in cell culture within 15 seconds. These antiseptics were completely effective at 1:100 and 1:5 dilutions, respectively. Therefore, use of these products according to the manufacturer's instructions (i.e. undiluted) for routine disinfection of hands following contact with HIV-contaminated materials, as well as immediate disinfection of abrasions or cuts exposed to HIV, should have significant protective effects. © 1990.

引用

页码：279 / 282

页数：4

共 9 条

[1]

KALYANARAMAN VS, 1984, SCIENCE, V225, P321, DOI 10.1126/science.6330889

[2] HIGH PREVALENCE OF ANTIBODIES TO ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS)-ASSOCIATED RETROVIRUS (ARV) IN AIDS AND RELATED CONDITIONS BUT NOT IN OTHER DISEASE STATES [J].