TOXICITY OF ALDEHYDE PRODUCTS OF LIPID-PEROXIDATION TO ADULT SCHISTOSOMA-INTERCALATUM INVITRO

被引：4

作者：

BARRETT, J

机构：

[1] Department of Biological Sciences, University College of Wales, Aberystwyth

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1991年 / 21卷 / 08期

基金：

英国医学研究理事会;

关键词：

LIPID PEROXIDATION; TOXIC ALDEHYDES; SCHISTOSOMA-INTERCALATUM;

D O I：

10.1016/0020-7519(91)90176-8

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The host's immune response results in oxidative damage to parasite membranes. Known aldehyde breakdown products from lipid peroxidation have been investigated for their in vitro toxicity to Schistosoma intercalatum. Saturated and monounsaturated aldehydes were found to be relatively non-toxic, whilst dienal and hydroxyenal aldehydes had LD50 values in the range of 10-20-mu-M. Conversion of the toxic aldehydes to their corresponding alcohols or glutathione conjugates reduced toxicity to S. intercalatum by one or two orders of magnitude. This suggests that parasite detoxification enzymes might be useful targets for chemotherapy and raises the possibility of combining chemo- and immunotherapy.

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页码：975 / 977

页数：3

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