ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION OF BACTERIA-DERIVED HYALURONIC-ACID IN RATS AND RABBITS

被引：20

作者：

NIMROD, A

EZRA, E

EZOV, N

NACHUM, G

PARISADA, B

机构：

[1] BioTechnology General (Israel) Ltd., Kiryat Weizmann, Rehovot

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1992年 / 8卷 / 02期

关键词：

D O I：

10.1089/jop.1992.8.161

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The feasibility of using bacteria-derived hyaluronate solution as a viscous aid for anterior chamber surgery was examined by studying the pharmacokinetic behavior and metabolic fate of C-14-labelled material, following administration to rats and rabbits. Intravenously-administered HA disappeared rapidly from the blood of rabbits and rats with a mean t1/2 of 5.3 and 3.7 min, respectively. The labelled material has concomittantly accumulated in the liver, where it was digested to oligomeric sugar subunits; these were further utilized metabolically either for energy generation or for incorporation into new high molecular weight species. Metabolic cage studies has indicated that most of the C-14-HA label administered intravenously to rats was excreted as CO2 via the respiration within 24h, while a smaller portion was excreted in the urine. The disposition of viscous C-14-HA administered into the anterior eye chamber of rabbits was slow and followed first-order kinetics with a t1/2 of 10.5h. No degradation occurred in the aqueous humour. Low blood levels of C-14-labeled material were found during 72h after intra-ocular administration. The results indicate that the absorption, disribution, metabolism and excretion of bacteria-derived HA is similar to those of the currently used ophthalmic surgery HA aids extracted from rooster combs.

引用

页码：161 / 172

页数：12

共 11 条

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