FRAMEWORK MULTIPOINT MAP OF THE LONG ARM OF HUMAN CHROMOSOME-4 AND TELOMERIC LOCALIZATION OF THE GENE FOR FSHD

被引:8
作者
WEIFFENBACH, B
BAGLEY, RG
FALLS, K
DUBOIS, J
HYSER, C
STORVICK, D
SCHULTZ, P
MENDELL, JR
MILNER, ECB
JACOBSEN, SJ
GRIGGS, RC
机构
[1] COLLABORAT RES INC,WALTHAM,MA 02154
[2] UNIV ROCHESTER,DEPT NEUROL,ROCHESTER,NY 14642
[3] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,LA JOLLA,CA 92093
[4] OHIO STATE UNIV,DEPT NEUROL,COLUMBUS,OH 43210
[5] VIRGINIA MASON RES CTR,SEATTLE,WA 98101
[6] UNIV CALIF SAN DIEGO,DEPT PEDIAT,LA JOLLA,CA 92093
关键词
D O I
10.1007/BF00352458
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mapping the long arm of Chromosome (Chr) 4 has assumed medical relevance with the establishment of linkage of facioscapulohumeral muscular dystrophy (FSHD) to distal 4q markers. We have constructed a multipoint linkage map using DNA markers that map to the long arm of Chr 4. Segregation data were collected for 17 DNA markers on the multigenerational CEPH mapping families, and data for one marker were taken from the published CEPH database. Genotypic information for six of these markers was also collected from a set of 24 families that exhibited inheritance of FSHD. Multipoint analyses allowed us to construct a map of 12 loci, connecting two previously separate linkage groups. Significant sex-specific differences in recombination were found for some genetic intervals. Four loci from the distal region of this map showed linkage with FSHD. A map using these terminal markers gave the strongest support for FSHD in the most distal position over all other possible positions.
引用
收藏
页码:143 / 150
页数:8
相关论文
共 29 条
[1]   A HIGHLY POLYMORPHIC VNTR LOCUS ON THE LONG ARM OF CHROMOSOME-4 [J].
ALTHERR, MR ;
WASMUTH, JJ ;
NAKAMURA, Y ;
WHITE, R .
NUCLEIC ACIDS RESEARCH, 1991, 19 (05) :1168-1168
[2]  
BOTSTEIN D, 1980, AM J HUM GENET, V32, P314
[3]  
BOWDEN DW, 1989, AM J HUM GENET, V44, P671
[4]   A GENETIC-LINKAGE MAP OF 32-LOCI ON HUMAN CHROMOSOME-10 [J].
BOWDEN, DW ;
GRAVIUS, TC ;
GREEN, P ;
FALLS, K ;
WURSTERHILL, D ;
NOLL, W ;
MULLERKAHLE, H ;
DONISKELLER, H .
GENOMICS, 1989, 5 (04) :718-726
[5]   A DETAILED MULTIPOINT GENE MAP OF CHROMOSOME-1Q [J].
BUETOW, KH ;
NISHIMURA, D ;
GREEN, P ;
NAKAMURA, Y ;
JIANG, O ;
MURRAY, JC .
GENOMICS, 1990, 8 (01) :13-21
[6]  
BUETOW KH, 1991, AM J HUM GENET, V48, P911
[7]   RFLP FOR INTRON-E OF FACTOR-XI GENE [J].
BUTLER, MG ;
PARSONS, AD .
NUCLEIC ACIDS RESEARCH, 1990, 18 (17) :5327-5327
[8]  
DONISKELLER H, 1989, CYTOGENET CELL GENET, V51, P991
[9]   A GENETIC-LINKAGE MAP OF THE HUMAN GENOME [J].
DONISKELLER, H ;
GREEN, P ;
HELMS, C ;
CARTINHOUR, S ;
WEIFFENBACH, B ;
STEPHENS, K ;
KEITH, TP ;
BOWDEN, DW ;
SMITH, DR ;
LANDER, ES ;
BOTSTEIN, D ;
AKOTS, G ;
REDIKER, KS ;
GRAVIUS, T ;
BROWN, VA ;
RISING, MB ;
PARKER, C ;
POWERS, JA ;
WATT, DE ;
KAUFFMAN, ER ;
BRICKER, A ;
PHIPPS, P ;
MULLERKAHLE, H ;
FULTON, TR ;
NG, S ;
SCHUMM, JW ;
BRAMAN, JC ;
KNOWLTON, RG ;
BARKER, DF ;
CROOKS, SM ;
LINCOLN, SE ;
DALY, MJ ;
ABRAHAMSON, J .
CELL, 1987, 51 (02) :319-337
[10]   A POLYMORPHIC DNA MARKER GENETICALLY LINKED TO HUNTINGTONS-DISEASE [J].
GUSELLA, JF ;
WEXLER, NS ;
CONNEALLY, PM ;
NAYLOR, SL ;
ANDERSON, MA ;
TANZI, RE ;
WATKINS, PC ;
OTTINA, K ;
WALLACE, MR ;
SAKAGUCHI, AY ;
YOUNG, AB ;
SHOULSON, I ;
BONILLA, E ;
MARTIN, JB .
NATURE, 1983, 306 (5940) :234-238