EFFECT OF MONOMETHYLMETHACRYLATE ON PROCOAGULANT ACTIVITIES OF HUMAN MONOCYTES AND UMBILICAL VEIN ENDOTHELIAL-CELLS IN-VITRO

被引:23
作者
DAHL, OE [1 ]
WESTVIK, AB [1 ]
KIERULF, P [1 ]
LYBERG, T [1 ]
机构
[1] UNIV OSLO,ULLEVAAL HOSP,DEPT CLIN CHEM,N-0407 OSLO,NORWAY
关键词
COAGULATION; MONOCYTES; ENDOTHELIAL CELLS; TISSUE FACTOR; THROMBIN; METHYLMETHACRYLATE MONOMER;
D O I
10.1016/0049-3848(94)90153-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cemented total hip replacement surgery is associated with intraoperative cardiorespiratory depression and postoperative proximal deep vein thrombosis which may be linked to an extreme intraoperative thrombin generation and local and systemic effects of monomethylmethyacrylate (MMA) released into circulation from curing cement. This in vitro study demonstrates that MMA alone or in combination with thrombin have effects on monocytes and human umbilical vein endothelial cells (HUVEC) which modulate their procoagulant activities. Moderate doses of MMA had a slight tissue factor (TF) inducing effect on monocytes. Small doses of MMA (0.1-1 mu g/ml) markedly potentiated the TF inducing effect of thrombin of lipopolysaccharide (LPS) which was included as a reference stimulant. These TF modulating effects of MMA were not seen with HUVEC. However, the generation of fibrinopeptide A(FPA) in cell overlay plasma indicated enhanced procoagulant activity of HUVEC treated with moderate doses of MMA, probably reflecting MMA cytotoxicity leading to cell retraction and exposure of extracellular matrix. Furthermore, small doses of MMA had a slight enhancing effect on FPA generation when coincubated with thrombin. These findings indicate that MMA in concentrations found in central venous blood in vivo, alone or together with thrombin, directly or indirectly exert effects that contribute to activation of coagulation.
引用
收藏
页码:377 / 387
页数:11
相关论文
共 40 条
  • [1] PULMONARY MICROVASCULAR FAT IN LUNG INJURY - AN EPIPHENOMENON
    BONE, RC
    [J]. CRITICAL CARE MEDICINE, 1993, 21 (05) : 644 - 644
  • [2] 2ND-DEGREE ATRIOVENTRICULAR-BLOCK AFTER METHYL-METHACRYLATE
    BROWN, DL
    PARMLEY, CL
    [J]. ANESTHESIOLOGY, 1982, 56 (05) : 391 - 392
  • [3] SEQUENTIAL INTRAPULMONARY AND SYSTEMIC ACTIVATION OF COAGULATION AND FIBRINOLYSIS DURING AND AFTER TOTAL HIP-REPLACEMENT SURGERY
    DAHL, OE
    PEDERSEN, T
    KIERULF, P
    WESTVIK, AB
    LUND, P
    ARNESEN, H
    SELJEFLOT, I
    ABDELNOOR, M
    LYBERG, T
    [J]. THROMBOSIS RESEARCH, 1993, 70 (06) : 451 - 458
  • [4] INTRAPULMONARY THROMBIN GENERATION AND ITS RELATION TO MONOMETHYLMETHACRYLATE PLASMA-LEVELS DURING HIP-ARTHROPLASTY
    DAHL, OE
    JOHNSEN, H
    KIERULF, P
    MOLNAR, I
    RO, JS
    VINJE, A
    MOWINCKEL, P
    [J]. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1992, 36 (04) : 331 - 335
  • [5] STUDIES ON COAGULATION, FIBRINOLYSIS, KALLIKREIN-KININ AND COMPLEMENT ACTIVATION IN SYSTEMIC AND PULMONARY CIRCULATION DURING HIP-ARTHROPLASTY WITH ACRYLIC CEMENT
    DAHL, OE
    MOLNAR, I
    VINJE, A
    RO, JS
    KIERULF, P
    ANDERSEN, ABW
    DALAKER, K
    PRYDZ, H
    [J]. THROMBOSIS RESEARCH, 1988, 50 (06) : 875 - 884
  • [6] DAHL OE, 1988, THROMB RES, V5, P865
  • [7] DAHL OE, 1993, IN PRESS ACTA ORTHOP
  • [8] INTRA-OPERATIVE COLLAPSE OR DEATH RELATED TO THE USE OF ACRYLIC CEMENT IN HIP-SURGERY
    DUNCAN, JAT
    [J]. ANAESTHESIA, 1989, 44 (02) : 149 - 153
  • [9] CEMENTED VERSUS NONCEMENTED TOTAL HIP-ARTHROPLASTY - EMBOLISM, HEMODYNAMICS, AND INTRAPULMONARY SHUNTING
    ERETH, MH
    WEBER, JG
    ABEL, MD
    LENNON, RL
    LEWALLEN, DG
    ILSTRUP, DM
    REHDER, K
    [J]. MAYO CLINIC PROCEEDINGS, 1992, 67 (11) : 1066 - 1074
  • [10] FAIRMAN RP, 1984, AM REV RESPIR DIS, V130, P92