A NEW ANTIBIOTIC, OKICENONE .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL CHARACTERISTICS

被引：8

作者：

KOMIYAMA, K

FUNAYAMA, S

ANRAKU, Y

ISHIBASHI, M

TAKAHASHI, Y

KAWAKAMI, T

OMURA, S

机构：

[1] KITASATO UNIV,KITASATO INST,5-9-1 SHIROKANE,MINATO KU,TOKYO 108,JAPAN

[2] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 08期

关键词：

D O I：

10.7164/antibiotics.44.814

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new antibiotic, okicenone was isolated from the culture broth of Streptomyces sp. KO-3599. The antibiotic possesses cytocidal activity against mammalian tumor cells in vitro at concentrations of 0.53 approximately 11.0-mu-g/ml whereas the antibiotic showed no antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000-mu-g/ml.

引用

页码：814 / 818

页数：5

共 11 条

[1]

ALLEY MC, 1988, CANCER RES, V48, P589

[2] A NEW ANTIBIOTIC, OKICENONE .2. PHYSICOCHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION [J].