COOPERATIVE BINDING OF HSP60 MAY PROMOTE TRANSFER HSP70 AND CORRECT FOLDING OF IMPORTED PROTEINS IN MITOCHONDRIA

被引：8

作者：

ENDO, T

机构：

[1] Department of Chemistry, Faculty of Science, Nagoya University, Chikusa-ku, Nagoya

来源：

FEBS LETTERS | 1991年 / 293卷 / 1-2期

关键词：

MOLECULAR CHAPERONE; HSP70; HSP60; MITOCHONDRION; PROTEIN IMPORT;

D O I：

10.1016/0014-5793(91)81139-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

I propose that a molecular chaperone hsp60 binds to and dissociates from the unfolded polypeptide or folding intermediate in a positively co-operative manner, but another chaperone hsp70 shows no such co-operativity. This could simply explain the fact that the protein newly imported in the mitochondrial matrix is transferred from hsp70 to hsp60 and hsp60 promotes correct folding of the substrate protein while hsp70 does not.

引用

收藏

页码：1 / 3

页数：3

相关论文

共 19 条

[1] MITOCHONDRIAL PROTEINS ESSENTIAL FOR VIABILITY MEDIATE PROTEIN IMPORT INTO YEAST MITOCHONDRIA [J].

BAKER, KP ;

SCHATZ, G .

NATURE, 1991, 349 (6306) :205-208

[2] HOW DOES PROTEIN FOLDING GET STARTED [J].

BALDWIN, RL .

TRENDS IN BIOCHEMICAL SCIENCES, 1989, 14 (07) :291-294

[3] STRUCTURE-FUNCTION RELATIONSHIP IN BINDING OF SNAKE NEUROTOXINS TO TORPEDO MEMBRANE RECEPTOR [J].

CHICHEPORTICHE, R ;

VINCENT, JP ;

KOPEYAN, C ;

SCHWEITZ, H ;

LAZDUNSKI, M .

BIOCHEMISTRY, 1975, 14 (10) :2081-2091

[4]

Creighton T. E., 1984, PROTEINS

[5] MOLECULAR CHAPERONES - UNFOLDING PROTEIN FOLDING [J].

CREIGHTON, TE .

NATURE, 1991, 352 (6330) :17-18

[6] MOLECULAR CHAPERONES [J].

ELLIS, RJ ;

VANDERVIES, SM .

ANNUAL REVIEW OF BIOCHEMISTRY, 1991, 60 :321-347

[7] PEPTIDE BINDING AND RELEASE BY PROTEINS IMPLICATED AS CATALYSTS OF PROTEIN ASSEMBLY [J].

FLYNN, GC ;

CHAPPELL, TG ;

ROTHMAN, JE .

SCIENCE, 1989, 245 (4916) :385-390

[8] RECONSTITUTION OF ACTIVE DIMERIC RIBULOSE BISPHOSPHATE CARBOXYLASE FROM AN UNFOLDED STATE DEPENDS ON 2 CHAPERONIN PROTEINS AND MG-ATP [J].

GOLOUBINOFF, P ;

CHRISTELLER, JT ;

GATENBY, AA ;

LORIMER, GH .

NATURE, 1989, 342 (6252) :884-889

[9] REQUIREMENT FOR HSP70 IN THE MITOCHONDRIAL MATRIX FOR TRANSLOCATION AND FOLDING OF PRECURSOR PROTEINS [J].

KANG, PJ ;

OSTERMANN, J ;

SHILLING, J ;

NEUPERT, W ;

CRAIG, EA ;

PFANNER, N .

NATURE, 1990, 348 (6297) :137-143

[10] THE MOLTEN GLOBULE STATE AS A CLUE FOR UNDERSTANDING THE FOLDING AND COOPERATIVITY OF GLOBULAR-PROTEIN STRUCTURE [J].

KUWAJIMA, K .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 1989, 6 (02) :87-103