One week treatment for Helicobacter pylori infection: A randomised study of quadruple therapy versus triple therapy

This study evaluated one week of quadruple therapy as treatment for Helicobacter pylori infection. Sixty duodenal ulcer patients were randomised to receive either standard triple therapy (tripotassium dicitrato bismuthate 120 mg qds + tetracycline 500 mg qds + metronidazole 400 mg qds), quadruple therapy A (triple therapy + omeprazole 20 mg od) or quadruple therapy B (triple therapy + omeprazole 40 mg ed), for 7 days. H. pylori eradication rates were 65%, 60% and 60%, respectively, with no significant differences between the groups. These results suggest that quadruple therapy provides no benefits over one week of triple therapy for treatment of H. pylori infection.