Subregion-specific modulation of excitatory input and dopaminergic output in the striatum by tonically activated glycine and GABA(A) receptors

被引：24

作者：

Adermark, Louise ^{[1
]}

Clarke, Rhona B. C. ^{[1
]}

Ericson, Mia ^{[1
]}

Soderpalm, Bo ^{[1
]}

机构：

[1] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, POB 410, S-40530 Gothenburg, Sweden

来源：

FRONTIERS IN SYSTEMS NEUROSCIENCE | 2011年 / 5卷

基金：

英国医学研究理事会;

关键词：

basal ganglia; dorsolateral striatum; nucleus accumbens; rat;

D O I：

10.3389/fnsys.2011.00085

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The flow of cortical information through the basal ganglia is a complex spatiotemporal pattern of increased and decreased firing. The striatum is the biggest input nucleus to the basal ganglia and the aim of this study was to assess the role of inhibitory GABA(A) and glycine receptors in regulating synaptic activity in the dorsolateral striatum (DLS) and ventral striatum (nucleus accumbens, nAc). Local field potential recordings from coronal brain slices of juvenile and adult Wistar rats showed that GABA(A) receptors and strychnine-sensitive glycine receptors are tonically activated and inhibit excitatory input to the DLS and to the nAc. Strychnine-induced disinhibition of glutamatergic transmission was insensitive to the muscarinic receptor inhibitor scopolamine (10 mu M), inhibited by the nicotinic acetylcholine receptor antagonist mecamylamine (10 mu M) and blocked by GABA(A) receptor inhibitors, suggesting that tonically activated glycine receptors depress excitatory input to the striatum through modulation of cholinergic and GABAergic neurotransmission. As an end-product example of striatal GABAergic output in vivo we measured dopamine release in the DLS and nAc by microdialysis in the awake and freely moving rat. Reversed dialysis of bicuculline (50 mu M in perfusate) only increased extrasynaptic dopamine levels in the nAc, while strychnine administered locally (200 mu M in perfusate) decreased dopamine output by 60% in both the DLS and nAc. Our data suggest that GABA(A) and glycine receptors are tonically activated and modulate striatal transmission in a partially subregion-specific manner.

引用

页数：10

共 53 条

[1]

Adermark L., Clarke R.B., Olsson T., Hansson E., Soderpalm B., Ericson M., Implications for glycine receptors and astro-cytes in ethanol-induced elevation of dopamine levels in the nucleus accumbens, Addict. Biol, 16, pp. 43-54, (2011)

[2]

Adermark L., Lovinger D.M., Frequency-dependent inversion of net striatal output by endocannabinoid-dependent plasticity at different synaptic inputs, J. Neurosci, 29, pp. 1375-1380, (2009)

[3]

Atono Y., Saigusa T., Mizoguchi N., Iwakami T., Takada K., Gionhaku N., Oi Y., Ueda K., Koshikawa N., Cools A.R., Role of GABAA receptors in the endomorphin-1-, but not endomorphin-2-, induced dopamine efflux in the nucleus accumbens of freely moving rats, Eur. J. Pharmacol, 580, pp. 87-94, (2008)

[4]

Blomqvist O., Engel J.A., Niss-Brandt H., Soderpalm B., The mesolimbic dopamine-activating properties of ethanol are antagonized bymecamylamine, Eur. J. Pharmacol, 249, pp. 207-213, (1993)

[5]

Blomqvist O., Ericson M., Engel J.A., Soderpalm B., Accumbal dopamine overflow after ethanol: Localization of the antagonizing effect of mecamylamine, Eur. J. Pharmacol, 334, pp. 149-156, (1997)

[6]

Bolam J.P., Hanley J.J., Booth P.A., Bevan M.D., Synaptic organisation of the basal ganglia, J. Anat, 196, pp. 527-542, (2000)

[7]

Charara A., Pare J.F., Levey A.I., Smith Y., Synaptic and extrasynaptic GABA-AandGABA-B receptors in the globus pallidus: An electron microscopic immunogold analysis in monkeys, Neuroscience, 131, pp. 917-933, (2005)

[8]

Chevalier G., Deniau J.M., Disinhibition As a Basic Process In the Expression of Striatal Functions.Trends Neurosci, 13, pp. 277-280, (1990)

[9]

Churchill L., Bourdelais A., Austin M., Zahm D.S., Kalivas P.W., Gamma-aminobutyric acid and mu-opioid receptor localization and adaptation in the basal fore-brain, Adv. Exp. Med. Biol, 584, pp. 01-117, (1991)

[10]

Clarke R.B., Adermark L., Acute ethanol treatment prevents endocannabinoid-mediated long-lasting disinhibition of striata] output, Neuropharmacology, 58, pp. 799-805, (2010)

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