MICROGLIA PROGENITOR CELLS - A SUBPOPULATION IN CULTURES OF MOUSE NEOPALLIAL ASTROGLIA

被引：54

作者：

RICHARDSON, A ^{[1
]}

HAO, C ^{[1
]}

FEDOROFF, S ^{[1
]}

机构：

[1] UNIV SASKATCHEWAN, DEPT ANAT, SASKATOON S7N 0W0, SASKATCHEWAN, CANADA

来源：

GLIA | 1993年 / 7卷 / 01期

关键词：

TROPHIC FACTOR; CSF-1; LIMITING DILUTION ANALYSIS;

D O I：

10.1002/glia.440070107

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have shown that astroglia cultures initiated from newborn mouse neopallium contain microglia progenitor cells. Astroglia secrete growth factor(s) that transform the progenitor cells into microglia. One of the trophic factors is bone marrow macrophage growth factor CSF-1. Mouse embryonic fibroblast cells STO also secrete trophic factor(s) that acts synergistically or additively with CSF-1 on microglia progenitor cells. Using limiting dilution analysis we estimated that in the presence of CSF-1 and STO cells, 1 in every 8 cells in astroglia cultures is a potential microglia progenitor cell.

引用

页码：25 / 33

页数：9

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