PHOSPHATASE INHIBITION BY CALYCULIN-A INCREASES IF IN CANINE PURKINJE-FIBERS AND MYOCYTES

被引：32

作者：

YU, HG ^{[1
]}

CHANG, F ^{[1
]}

COHEN, IS ^{[1
]}

机构：

[1] SUNY STONY BROOK,HSC,DEPT PHYSIOL & BIOPHYS,STONY BROOK,NY 11794

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1993年 / 422卷 / 06期

关键词：

PACEMAKER CURRENT; PHOSPHORYLATION; IF; PURKINJE MYOCYTE;

D O I：

10.1007/BF00374010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The actions of the phosphatase inhibitor calyculin A on the pacemaker current i(f) were studied in canine Purkinje fibers and myocytes. Calyculin A increased i(f) in response to hyperpolarizations toward the middle of the i(f) activation curve. A three pulse protocol indicated this increase was due to a positive shift of i(f) activation on the voltage axis. Taken together with our previous results (that kinase inhibition with H7 shifts i(f) activation in the negative direction on the voltage axis (2)), these results suggest that phosphorylation is an important regulator of the voltage dependence of i(f) activation.

引用

页码：614 / 616

页数：3

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