LEVODOPA PEAK RESPONSE-TIME REFLECTS SEVERITY OF DOPAMINE NEURON LOSS IN PARKINSONS-DISEASE

被引：33

作者：

SOHN, YH ^{[1
]}

METMAN, LV ^{[1
]}

BRAVI, D ^{[1
]}

LINFANTE, I ^{[1
]}

AOTSUKA, A ^{[1
]}

MOURADIAN, MM ^{[1
]}

CHASE, TN ^{[1
]}

机构：

[1] NINCDS,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892

来源：

NEUROLOGY | 1994年 / 44卷 / 04期

关键词：

D O I：

10.1212/WNL.44.4.755

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We measured the time to peak antiparkinson response following injection of levodopa or apomorphine in 57 patients with Parkinson's disease. The peak response time for levodopa fell from 53 +/- 6.5 minutes in patients at Hoehn and Yahr stage I-II, and 28 +/- 4.8 minutes in those at stage TV (p < 0.0005). There was a significant correlation between levodopa peak response time and symptom duration (r = 0.65; p < 0.0001), but there was no relation between apomorphine peak response time and measures of disease severity. Peak response time to levodopa appears to reflect predominantly the status of compensatory presynaptic dopaminergic mechanisms and thus may provide an index to the degree of dopamine neuron degeneration in parkinsonian patients.

引用

页码：755 / 757

页数：3

共 10 条

[1] HYPERACTIVITY OF REMAINING DOPAMINERGIC NEURONS AFTER PARTIAL DESTRUCTION OF NIGRO-STRIATAL DOPAMINERGIC SYSTEM IN RAT [J].